2011 Fiscal Year Final Research Report
Analysis of denaturated protein in the central nervous system and endocrine system of drug abusers
| Project/Area Number |
21790612
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Osaka City University |
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Principal Investigator |
ISHIKAWA Takaki 大阪市立大学, 大学院・医学研究科, 准教授 (50381984)
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| Research Collaborator |
HITOSHI Maeda 大阪市立大学, 大学院・医学研究科, 教授 (20135049)
TOMOMI Michiue 大阪市立大学, 大学院・医学研究科, 講師 (00529240)
MASAFUMI Tomita 川崎医科大学, 准教授 (50113197)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 社会医学 / 細胞 / 組織 / ストレス / 蛋白質 / 薬物乱用 |
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| Research Abstract |
This study analyzed the expression dynamics of apoliprotein(Apo) E4, ApoB, and ApoJ, which are known to be increased in cases with neurodegenerative diseases such as Alzheimer's disease and Creutzfeldt-Jakob disease, in the central nervous system and endocrine system of metamphetamine and psychotropic drug abusers using immunohistochemical and molecular biological(mRNA expression) techniques. Although Apo expression showed site-to-site differences, characteristic expression patterns were detected not only in cases exposed to extreme temperature conditions in traumatic events, such as fire fatality, hyperthermia, or hypothermia, but also in drug abusers.
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