The mechanism of prevention of vascular senescence by Sirtuin

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790621
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: The University of Tokyo
• Principal Investigator: OTA Hidetaka The University of Tokyo, 医学部附属病院, 特任臨床医 (20431869)
• Project Period (FY): 2009 – 2010
• Keywords: SIRT1 / eNOS / 抗老化 / 血管老化

Research Abstract

Our results indicated that cilostazol or statins exerted protective effects against endothelial senescence and dysfunction, and enhancement of NO production is a key mediator in up-regulation of SIRT1.

Research Products

• [Journal Article] Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway. (2010)
  • Author(s): Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi Y
  • Journal Title: Arterioscler Thromb Vasc Biol. 30(11) Pages: 2205-2211
  • Peer Reviewed
• [Journal Article] SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis. (2010)
  • Author(s): Ota H, Eto M, Ogawa S, Iijima K, Akishita M, Ouchi Y
  • Journal Title: J Atheroscler Thromb. 17(5) Pages: 431-435
  • Peer Reviewed
• [Journal Article] Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation : therapeutic implication of cilostazol after drug-eluting stent implantation. (2009)
  • Author(s): Ota H, Eto M, Ako J, Ogawa S, Iijima K, Akishita M, Ouchi Y
  • Journal Title: J Am Coll Cardiol. 53(24) Pages: 2298-2305
  • Peer Reviewed
• [Presentation] シンポジウム14「血管のアンチエイジング-血管から老いないために」スタチンによる血管老化抑制機構 (2010)
  • Author(s): 大田秀隆
  • Organizer: 第10回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 20100612-20100613
• [Presentation] SIRT1/eNOS axis inhibits vascular senescence, dysfunction and atherosclerosis. (2010)
  • Author(s): Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi Y
  • Organizer: ISHR 2010
  • Place of Presentation: kyoto, Japan
  • Year and Date: 2010-05-15