A Study of efficacy of Daikenchuto for NSAIDs-induced small bowel injuries

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790626
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Osaka University
• Principal Investigator: ARIMITSU Junsuke Osaka University, 医学系研究科, 寄附講座助教 (60457009)
• Project Period (FY): 2009 – 2010
• Keywords: 大建中湯 / NSAIDs / 小腸潰瘍 / 東洋医学

Research Abstract

Daikenchuto(DKT) inhibited productions of inflammation related cytokines such as IL-12(p40), IL-16, IL-17, IL-18, TRAIL, MIP1-α, TNF-α for volunteers who took NSAIDs. Capsule endoscopy scoring index for small bowel mucosal inflammatory change in the DKT group were lower than in the placebo group. This study suggested that DKT has efficacy in preventing NSAIDs-induced small bowel injuries.