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2010 Fiscal Year Final Research Report

Inhibitory role of brain endocannabinoid in central activation of sympatho-adrenomedullary outflow

Research Project

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Project/Area Number 21790627
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionKochi University

Principal Investigator

SHIMIZU Takahiro  Kochi University, 教育研究部医療学系, 助教 (00363276)

Project Period (FY) 2009 – 2010
Keywords中枢性交感神経ー副腎髄質系 / ホスホリパーゼC / ジアシルグリセロールリパーゼ / 2-アラキドノイルグリセロール / モノアシルグリセロールリパーゼ / アラキドン酸 / 脳内大麻 / エンドカンナビノイド
Research Abstract

We examined the roles of brain endocannabinoid (eCB) in regulation of central activation of sympatho-adrenomedullary (SA) outflow using anesthetized rats. 2-Arachidonoylglycerol (2-AG), an eCB, was endogenously generated in the brain during the central activation of SA outflow. This 2-AG played a promotional role as a precursor of arachidonic acid and also an inhibitory role as an eCB in the activation. These findings suggest that brain 2-AG has bidirectional roles in the central activation of SA outflow. Taken together, brain eCB can be a beneficial target for therapeutic drugs to modulate the outflow.

  • Research Products

    (13 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results)

  • [Journal Article] Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in bombesin-induced activation of central adrenomedullary outflow in rats.2011

    • Author(s)
      Shimizu T, Lu L, Yokotani K.
    • Journal Title

      Eur.J.Pharmacol. 658

      Pages: 123-131

    • Peer Reviewed
  • [Journal Article] Brain τ4β2 nicotinic acetylcholine receptors are involved in the secretion of noradrenaline and adrenaline from adrenal medulla in rats.2011

    • Author(s)
      Shimizu T, Tanaka K, Hasegawa T, Yokotani K.
    • Journal Title

      Eur.J.Pharmacol. 654

      Pages: 241-248

    • Peer Reviewed
  • [Journal Article] Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats.2010

    • Author(s)
      Shimizu T, Lu L, Yokotani K.
    • Journal Title

      Eur.J.Pharmacol.高知大学学術情報リポジトリ 641

      Pages: 54-60

    • URL

      http://hdl.handle.net/10126/4650

    • Peer Reviewed
  • [Journal Article] Acute cold exposure-induced down-regulation of CIDEA, cell death-inducing DNA fragmentation factor-τ-like effector A, in rat interscapular brown adipose tissue by sympathetically activated β3-adrenoreceptors.2009

    • Author(s)
      Shimizu T, Yokotani K.
    • Journal Title

      Biochem.Biophys.Res.Commun.高知大学学術情報リポジトリ 387

      Pages: 294-299

    • URL

      http://hdl.handle.net/10126/3153

    • Peer Reviewed
  • [Presentation] 内因性に生成された脳内2-アラキドノイルグリセロールはボンベシンによる中枢性副腎髄質系賦活に対し二方向性の役割を示す2011

    • Author(s)
      清水孝洋、盧連依、横谷邦彦
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      (学会誌上開催)
    • Year and Date
      2011-02-15
  • [Presentation] Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in the bombesin-induced activation of central adrenomedullary outflow in rats.2010

    • Author(s)
      Shimizu T, Lu L, Yokotani K.
    • Organizer
      5th International Peptide Symposium
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-12-06
  • [Presentation] 脳内エンドカンナビノイドの中枢性交感神経-副腎髄質系賦活における抑制性制御2010

    • Author(s)
      清水孝洋、横谷邦彦
    • Organizer
      第38回薬物活性シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2010-11-12
  • [Presentation] 脳内エンドカンナビノイドはカンナビノイドCB_1受容体を介してボンベシンによる中枢性副腎髄質系賦活を抑制性に制御する2010

    • Author(s)
      清水孝洋、横谷邦彦
    • Organizer
      第63回日本自律神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-22
  • [Presentation] Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats.2010

    • Author(s)
      Shimizu T, Lu L, Yokotani K.
    • Organizer
      Keystone Symposia Conference: Bioactive lipids: Biochemistry and Diseases
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-06-09
  • [Presentation] Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in rats.2010

    • Author(s)
      Shimizu T, Lu L, Yokotani K.
    • Organizer
      The 14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-03-29
  • [Presentation] 内因性に生成された2-アラキドノイルグリセロールはコルチコトロピン放出因子による中枢性交感神経-副腎髄質系賦活に対し抑制性作用を示す2010

    • Author(s)
      清水孝洋、盧連依、横谷邦彦
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-16
  • [Presentation] 脳内エンドカンナビノイドはコルチコトロピン放出因子による中枢性交感神経-副腎髄質系賦活を抑制性に制御する2009

    • Author(s)
      清水孝洋、横谷邦彦
    • Organizer
      第62回日本自律神経学会総会
    • Place of Presentation
      和歌山
    • Year and Date
      2009-11-06
  • [Presentation] 急性寒冷曝露ラットの褐色脂肪組織において交感神経によるアドレナリンβ_3受容体の活性化によりCIDEA( cell death-inducing DNAfragmentation factor-τ-like effector A)の発現低下が惹起される2009

    • Author(s)
      清水孝洋、横谷邦彦
    • Organizer
      第13回活性アミンに関するワークショップ
    • Place of Presentation
      津
    • Year and Date
      2009-08-28

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Published: 2012-02-13   Modified: 2016-04-21  

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