2010 Fiscal Year Final Research Report
Role of COX and NOS in the presympathetic PVN neurons in restraint stress-induced sympathetic activation
| Project/Area Number |
21790628
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Tsukuba |
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Principal Investigator |
YAMAGUCHI Naoko University of Tsukuba, 大学院・人間総合科学研究科, 研究員 (50380324)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ストレス / シクロオキシゲナーゼ / 一酸化窒素合成酵素 / CRF / 視床下部室傍核 / 交感神経系 |
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| Research Abstract |
Stress is one of the important factors to activate the sympathetic nervous system. In this study, I investigated whether brain COX and NOS can mediate restraint stress-induced sympathetic activation in rats. The present results suggest that COX-1, COX-2 and inducible NOS, but not neuronal NOS, in the presympathetic PVN neurons mediate acute restraint stress-induced sympathetic activation.
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