2010 Fiscal Year Final Research Report
Involvement of orexin-A and neuropeptide Y in the antidepressant-like effect of kososan.
| Project/Area Number |
21790631
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kitasato University |
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Principal Investigator |
ITO Naoki Kitasato University, 東洋医学総合研究所, 上級研究員 (00370164)
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| Research Collaborator |
HANAWA Toshihiko 北里大学, 東洋医学総合研究所, 所長 (40164892)
OIKAWA Tetsuro 北里大学, 東洋医学総合研究所, 部長 (10370165)
YAMADA Haruki 北里大学, 北里生命科学研究所, 教授 (60096691)
YABE Takeshi 北里大学, 北里生命科学研究所, 講師 (40239835)
NAGAI Takayuki 北里大学, 北里生命科学研究所, 講師 (00172487)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 香蘇散 / 抗うつ様効果 / オレキシン / ニューロペプチド |
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| Research Abstract |
In the present study, our results raise the possibility that signal pathways from orexin to neuropeptide Y (NPY) system play crucial roles in an antidepressant-like effect of kososan. These findings suggest that the antidepressant-like effect of kososan is strongly associated with the regulation of orexinergic and NPYergic network, and we have partly uncovered the potential differences in the mechanisms underlying the antidepressant-like effects of kososan and of antidepressants. These findings may contribute to the development of antidepressants with novel mechanisms of action targeting the orexinergic and NPYergic system.
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