2010 Fiscal Year Final Research Report
Preventive effect of Kaempferia parviflora on metabolic Disease
| Project/Area Number |
21790634
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Musashino University |
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Principal Investigator |
SHIMADA Tsutomu Musashino University, 薬学研究所, 講師 (90409384)
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| Project Period (FY) |
2009 – 2010
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| Keywords | Kaempferia parviflora / TSOD / 3T3-L1細胞 / 脂肪蓄積抑制効果 / 脂肪分化促進作用 |
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| Research Abstract |
Kaempferia parviflora (KP), a Zingiberaceae plant, showed the preventive effects on metabolic diseases, including anti-obesity and improvement of insulin-resistance in spontaneously obese type II diabetic mice. Polymethoxylflavones, included in KP, enhanced the differentiation of adipocytes in vitro, suggesting that KP directly affected to adipocytes and improved insulin-resistance. In is concluded that KP is promising as a seed compound for developing therapeutic medicines or food for specified health use (FOSHU) for metabolic diseases.
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