2010 Fiscal Year Final Research Report
TNFSF15 derived from T cells may play an important role in the pathogenesis of Crohn's disease.
| Project/Area Number |
21790644
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
KAKUTA Yoichi Tohoku University, 大学院・医学系研究科, 非常勤講師 (50509205)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 炎症性腸疾患 / 感受性遺伝子 / TNFSF15 |
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| Research Abstract |
We analyzed the transcriptional mechanisms of TL1A induced by LPS using the human monocytic cell line U937, LPS induces TL1A expression through the transcriptional activation via a NF-kappa B pathway. The NF-kappa B binding site in the 5' flanking region of TL1A was identified.
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