2010 Fiscal Year Final Research Report
Pharmacogenetic study to predicting clinical response of oxaliplatin in patients with advanced colorectal cancer
| Project/Area Number |
21790661
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
KANAI Masashi Kyoto University, 医学研究科, 特定助教 (70432416)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUDA Fumihiko 京都大学, 医学研究科, 教授 (50212220)
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| Project Period (FY) |
2009 – 2010
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| Keywords | がん化学療法 / 薬理遺伝学 |
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| Research Abstract |
Susceptibility to oxaliplatin-induced neuropathy differs greatly among patients. In this study, we investigated the associations between oxaliplatin-induced neuropathy and the following polymorphisms : glutathione S-transferase p (GSTP1) Ile^<105>Val, and glyoxylate aminotransferase (AGXT) Pro^<11>Leu and AGXT Ile^<340>Met. Eighty-two Japanese patients with histologically confirmed colorectal cancer who received at least six cycles of the modified FOLFOX6 (m-FOLFOX6) regimen were enrolled.
There were more patients carrying at least one GSTP1^<105>Val allele among the group with grade 2/3 neuropathy han among the group with grade 1 neuropathy although the difference was not statistically significant (41% vs 24%, P=0.098). There were similar numbers of patients carrying at least one AGXT^<105>Met allele in the grade 2/3 neuropathy and grade 1 neuropathy groups (16% vs 13% ; P=0.725). The AGXT^<11>Leu allele was not found in any of our patients or controls.
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Research Products
(21 results)
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[Journal Article] Dose-escalation and pharmacokinetic study of nanoparticlecurcumin, apotential anticancer agent with improved bioavailability, in health human volunteers.2011
Author(s)
Kanai M, Imaizumi A, Otsuka Y, Sasaki H, Hashiguchi M, Tsujiko K, Matsumoto S,Ishiguro H, Chiba T.
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Journal Title
Cancer Chemother Pharmacol. (Epub ahead of print)
Peer Reviewed
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[Journal Article] A Case of Progressive Digital Ischemia after Early Withdrawal of Gemcitabine and S-1 in a Patient with Systemic Sclerosis.2011
Author(s)
Zaima C, Kanai M, Ishikawa S, Kawaguchi Y, Masui T, Mori Y, Nishimura T,Matsumoto S, Yanagihara K, Chiba T, Mimori T.
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Journal Title
Jpn J Clin Oncol. 41(6)
Pages: 803-806
Peer Reviewed
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[Journal Article] Aphase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer.2010
Author(s)
Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S, Nishimura T, Mori Y, Masui T, Kawaguchi Y, Yanagihara K, Yazumi S, Chiba T, Guha S, Aggarwal BB
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Journal Title
Cancer Chemother Pharmacol. 66(5)
Pages: 913-918
Peer Reviewed
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[Journal Article] A multi-institution phase II study of gemcitabine/S-1 combination chemotherapy for patients with advanced biliary tract cancer2010
Author(s)
Kanai M, Yoshimura K, Tsumura T, Asada M, Suzuki C, Niimi M, Matsumoto S, Nishimura T, Nitta T, Yasuchika K, Taura K, Mori Y, Hamada A, Inoue N, Tada S, Yanagihara K, Yazumi S, Osaki Y, Chiba T, Ikai I, Fukushima M, Uemoto S, Hatano E
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Journal Title
Cancer Chemother Pharmacol 67(6)
Pages: 1429-1434
Peer Reviewed
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[Journal Article] Premedication with 20 mg dexamethasone effectively prevents relapse of extensive skin rash associated with gemcitabine monotherapy2010
Author(s)
Kanai M, Matsumoto S, Nishimura T, Matsumura Y, Hatano E, Mori A, Masui T, Kawaguchi Y, Nakamura E, Tada S, Kitano T, Ishiguro H, Yanagihara K, Chiba T
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Journal Title
Ann Oncol. 21(1)
Pages: 189-190
Peer Reviewed
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[Journal Article] Associations between glutathione S-transferase pi Ile105Val and glyoxylate aminotransferase Pro11Leu and Ile340Met polymorphisms and early-onset oxaliplatin-induced neuropathy2010
Author(s)
Kanai M, Yoshioka A, Tanaka S et al.Kanai M, Yoshioka A, Tanaka S, Nagayama S, Matsumoto S, Nishimura T, Niimi M,Teramukai S, Takahashi R, Mori Y, Kitano T, Ishiguro H, Yanagihara K, Chiba T, Fukushima M, Matsuda F
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Journal Title
Cancer Epidemiology 34(2)
Pages: 189-193
Peer Reviewed
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[Journal Article] Phase II study of S-1 and docetaxel for previously treated patients with locally advanced or metastatic non-small cell lung cancer.2010
Author(s)
Yanagihara K, Yoshimura K, Niimi M, Yasuda H, Sasaki T, Nishimura T, Ishiguro H, Matsumoto S, Kitano T, Kanai M, Misawa A, Tada H, Teramukai S, Mio T, Fukushima M.
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Journal Title
Cancer Chemother Pharmacol. 66(5)
Pages: 913-918
Peer Reviewed
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[Journal Article] Oxaliplatin-free interval as a risk factor for hypersensitivity reaction among colorectal cancer patients treated with FOLFOX2010
Author(s)
Mori Y, Nishimura T, Kitano T, Yoshimura K, Matsumoto S, Kanai M, Hazama M, Ishiguro H, Nagayama S, Yanagihara K, Teramukai S, Chiba T, Sakai Y, Fukushima M
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Journal Title
Oncology. 79(1-2)
Pages: 136-143
Peer Reviewed
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