2011 Fiscal Year Final Research Report
WT1-specific immunological assessments in WT1-peptide-based cancer vaccine in combination with gemcitabine for patients with advanced pancreatic cancer
| Project/Area Number |
21790665
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
NISHIDA Sumiyuki 大阪大学, 大学院・医学系研究科, 寄附講座助教 (00403189)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 胆道学 / 膵臓学(膵臓癌) |
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| Research Abstract |
A clinical study of WT1-peptide-based cancer vaccine(WT1 vaccine) in combination with gemcitabine was performed for the patients with advanced pancreatic cancer. I focused on the association between clinical efficiency and WT1-specific immunological monitoring, such as i) delayed-type hypersensitivity(DTH) to WT1 peptide and ii) WT1-specific cytotoxic lymphocytes in the peripheral blood(WT1-CTLs). An association between longer survival and DTH-positivity was statistically significant, and longer survivors had higher frequency of WT1-CTLs with memory phenotype.
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