2010 Fiscal Year Final Research Report
Investigation of the effect of retinoids on hepatic iron overload in a mouse NAFLD model.
| Project/Area Number |
21790666
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto Pharmaceutical University (2010)
Tottori University (2009) |
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Principal Investigator |
TSUCHIYA Hiroyuki Kyoto Pharmaceutical University, 薬学部, 講師 (00403402)
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| Project Period (FY) |
2009 – 2010
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| Keywords | レチノイン酸 / 鉄代謝 / NAFLD / インスリン抵抗性 / 肝鉄過剰沈着 / NASH / レプチン / 肝脂肪沈着 |
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| Research Abstract |
Hepatic iron overload in non-alcoholic fatty liver disease (NAFLD) patients with steatosis and insulin resistance has been frequently observed in clinical settings. In this study, I found the close association between the iron overload and aberrant lipid deposition in the liver. Since I have previously clarified that retinoids have a potent effect on the hepatic iron metabolism, the pathological effect of a retinoid in mice with NAFLD was investigated. Consequently, the retinoid was found to markedly improve the insulin resistance in the mouse model in a leptin-dependent manner.
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