2010 Fiscal Year Final Research Report
Ribavirin regulates hepatitis C virus replication through the up-regulation of interferon-stimulated genes
| Project/Area Number |
21790670
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Ehime University |
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Principal Investigator |
TOKUMOTO Yoshio Ehime University, 医学部附属病院, 講師 (10533078)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 肝臓学 |
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| Research Abstract |
The combination therapy of interferon (IFN) and ribavirin (RBV) is used to treat HCV infection, however, how RBV enhances the anti-HCV effects remains unknown. We therefore investigated whether RBV modifies IFN's anti-HCV action. We used plasmid-based HCV replication system, which express HCV genotype 1a full genome in HepG2 and Huh7 hepatoma cell lines. Ribavirin regulates HCV replication through the up-regulation of ISGs induced by enhancing autocrine IFN-β. The modulation of ISGs by RBV would help to establish a means of eliminating HCV.
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