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2010 Fiscal Year Final Research Report

Development of liver cancer preventive methods using VA-Lip-siRNA

Research Project

  • PDF
Project/Area Number 21790674
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionSapporo Medical University

Principal Investigator

MURASE Kazuyuki  Sapporo Medical University, 医学部, 助教 (90444918)

Project Period (FY) 2007 – 2010
Keywords移植・再生医療 / 核酸 / 癌 / 再生医学 / 脂質
Research Abstract

In this study, we established liver fibrosis model using CDAA diet model and investigated the mechanism of liver carcinogenesis induced by fibrosis. Furthermore, we examined whether the resolution of collagen deposition by siRNA-HSP47 could prevent hepatic carcinoma using CDAA diet model. Finally, we could obtain the fundamental data regarding the plausible mechanisms of liver carcinogenesis by fibrosis which should be promising for prevention of liver fibrosis.

  • Research Products

    (6 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results)

  • [Journal Article] Two cases of myelodysplastic syndrome associated with pyoderma gangrenosum.2011

    • Author(s)
      Murase K, Sato T, Takimoto R, Kobune M, Kato J.
    • Journal Title

      Rinsho zasshi Naika. In press.

    • Peer Reviewed
  • [Journal Article] Tuberculous pleuritis with onset of refractory pleural effusion after chemoradiotherapy for esophageal cancer.2011

    • Author(s)
      Hirakawa M, Sato Y, Ohnuma H, Sagawa T, Ishiwatari H, Murase K, Iyama S, Hayashi T, Sato T, Miyanishi K, Kobune M, Takimoto R, Kato J.
    • Journal Title

      Nippon Shokakibyo Gakkai Zasshi 108(2)

      Pages: 231-237

    • Peer Reviewed
  • [Journal Article] Therapeutic results in patients with biphenotypic acute leukemia at Sapporo Medical University Hospital.2010

    • Author(s)
      Murase K, Iyama S, Sato T, Takimoto R, Kobune M, Kato J.
    • Journal Title

      Gan To Kagaku Ryoho 37(10)

      Pages: 2011-2013

    • Peer Reviewed
  • [Journal Article] Endoscopic findings of enteropathy-type T-cell lymphoma by double-balloon enteroscopy and capsule endoscopy.2010

    • Author(s)
      Sato Y, Ono M, Sagawa T, Takimoto R, Hirakawa M, Ohnuma H, Sato T, Iyama S, Murase K, Miyanishi K, Kobune M, Kato J.
    • Journal Title

      Dig Endosc 22(3)

      Pages: 243-245

    • Peer Reviewed
  • [Journal Article] Evaluation of the efficacy of liposomal amphotericin B.2010

    • Author(s)
      Iyama S, Murase K, Sato T, Kikuchi S, Sato Y, Kobune M, Takimoto R, Kato J.
    • Journal Title

      Kansenshogaku Zasshi 84(2)

      Pages: 182-186

    • Peer Reviewed
  • [Journal Article] Drug resistance is dramatically restored by hedgehog inhibitors in CD34^+ leukemic cells.2009

    • Author(s)
      Kobune M, Takimoto R, Murase K, Iyama S, Sato T, Kikuchi S, Kawano Y, Miyanishi K, Sato Y, Niitsu Y, Kato J.
    • Journal Title

      Cancer Sci 100(5)

      Pages: 948-955

    • Peer Reviewed

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Published: 2012-02-13   Modified: 2016-04-21  

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