Immunological Study of Autoimmune Extrapancreatic Exocrinopathy In Autoimmune Pancreatitis Animal Model

2011 Fiscal Year Final Research Report

• Project/Area Number: 21790689
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Kansai Medical University
• Principal Investigator: SAKAGUCHI Yutaku 関西医科大学, 学医学部, 助教 (60340692)
• Project Period (FY): 2009 – 2011
• Keywords: 自己免疫性膵炎 / 制御性T 細胞 / 全身性硬化病変 / Th-17 / WBN/Kob

Research Abstract

The activation of Th1/Th2 and regulatory T cell, producted IL-4, IL-10 that promoting the class switch to IgG2b. It suggested the involvement with the morbidity and aggravation in WBN/Kob rats.

Research Products

• [Journal Article] Attenuation of indomethacin-induced gastric mucosal injury by prophylactic administration of sake yeast-derived thioredoxin (2012)
  • Author(s): Nakajima A, Fukui T
  • Journal Title: J Gastroenterol Volume: 47(9) Pages: 978-87
  • Peer Reviewed
• [Journal Article] The similarity of Type 1 autoimmune pancreatitis to pancreatic ductal adenocarcinoma with significant IgG4-positive plasma cell infiltration (2012)
  • Author(s): Fukui Y, Uchida K, Sumimoto K, Kusuda T, Miyoshi H, Koyabu M, Ikeura T, Sakaguchi Y, Shimatani M, Fukui T, Matsushita M, Takaoka M, Nishio A, Shikata N, Sakaida N, Uemura Y, Satoi S, Kwon AH, Okazaki K
  • Journal Title: J Gastroenterol
  • Peer Reviewed
• [Journal Article] Dilatation of the Bile and Pancreatic Ducts due to Compression by an Unruptured Abdominal Aortic Aneurysm (AAA) : A Case Ameliorated by an Endovascular Stent Grafting (2012)
  • Author(s): T, Suzuki R, Sakaguchi Y, Shibatani N, Hachimine D, Uchida K, Nishio A, Seki T, Okazaki K
  • Journal Title: Intern Med Volume: 51(19) Pages: 2749-52
  • Peer Reviewed
• [Journal Article] Regulatory T cells in type 1 autoimmune pancreatitis (2012)
  • Author(s): Uchida K, Kusuda T, Koyabu M, Miyoshi H, Fukata N, Sumimoto K, Fukui Y, Sakaguchi Y, Ikeura T, Shimatani M, Fukui T, Matsushita M, Takaoka M, Nishio A, Okazaki K
  • Journal Title: Int J Rheumatol Volume: 2012 Pages: 795026
  • Peer Reviewed
• [Journal Article] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis (2011)
  • Author(s): Fukui T, Kishimoto M, Nakajima A,Yamashina M, Nakayama S, Kusuda T, Sakaguchi Y, Yoshida K, Uchida K, Nishio A, Matsuzaki K, Okazaki K.
  • Journal Title: J Gastroenterol Volume: 46(4) Pages: 456-68
  • Peer Reviewed
• [Journal Article] Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases (2010)
  • Author(s): Koyabu M, Uchida K, Miyoshi H, Sakaguchi Y, Fukui T, Ikeda H, Takaoka M, Hirohara J, Nishio A, Uemura Y, Uemoto S, Okazaki K
  • Journal Title: J Gastroenterol Volume: 45(7) Pages: 732-41
  • Peer Reviewed
• [Journal Article] Primary sclerosing cholangitis with elevated serum IgG4 levels and/or infiltration of abundant IgG4-positive plasma cells. J Gastroenterol (2010)
  • Author(s): Koyabu M, Uchida K, Fukata N, Kusuda T, Ikeura T, Sakaguchi Y, Yoshida K, Shimatani M, Fukui T, Matsushita M, Uemura Y, Kaibori M, Takaoka M,Nishio A, Okazaki K
  • Journal Title: J Gastroenterol Volume: 45(1) Pages: 122-9
  • Peer Reviewed
• [Journal Article] Idiopathic duct-centric pancreatitis (IDCP) with immunological studies (2010)
  • Author(s): Kusuda T, Uchida K, Satoi S, Koyabu M, Fukata N, Miyoshi H, Ikeura T, Sakaguchi Y, Yoshida K, Fukui T, Shimatani M, Matsushita M, Takaoka M, Nishio A, Uemura Y, Kwon AH, Okazaki K
  • Journal Title: Intern Med Volume: 49(23) Pages: 2569-75
  • Peer Reviewed
• [Journal Article] Long-term outcome of autoimmune pancreatitis (2009)
  • Author(s): Uchida K, Yazumi S, Nishio A, Kusuda T, Koyabu M, Fukata M, Miyoshi H, Sakaguchi Y, Fukui T, Matsushita M, Takaoka M, Okazaki K
  • Journal Title: J Gastroenterol Volume: 44(7) Pages: 726-32
  • Peer Reviewed
• [Presentation] AN ANIMAL MODEL FOR ACUTE,CHRONIC,AND SEVERE PANCREATITIS WITH THE ANALYSES OF REGENERATION MECHANISMS (2009)
  • Author(s): Y Sakaguchi,T Kusuda,M Koyabu,M Fukata,H Miyoshi,T Fukui,K Uchida,M Matsushita,M Takaoka,A Nishio, K Okazaki
  • Organizer: 40th Anniversary Joint Meeting of the American Pancreatic Association & Japan Pancreas Society
  • Place of Presentation: Honolulu,USA
  • Year and Date: 2009-11-07
• [Presentation] WBN/Kob ラットの慢性膵炎・膵外病変における自己免疫性機序の関与及び制御性T 細胞の免疫応答 (2009)
  • Author(s): 坂口雄沢、深田憲将、三好秀明、楠田武生、福井寿朗、内田一茂、西尾彰功、岡崎和一
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 北海道京王プラザホテル札幌
  • Year and Date: 2009-05-08