The interaction between the pathway of TWEAK-Fn14 and IL-13 in the intestinalepithelial cell regeneration

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790695
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Research Institute, International Medical Center of Japan
• Principal Investigator: KAWASHIMA Rei 独立行政法人国立国際医療研究センター, 研究所・肝炎・免疫研究センター消化器疾患研究部, 客員研究員 (70392389)
• Project Period (FY): 2009 – 2010
• Keywords: 消化管上皮細胞傷害 / サイトカイン / アポトーシス

Research Abstract

We demonstrate that TNF-α -induced intestinal epithelial cell damage partially dependend on TWEAK/Fn14 as well as IL-13. TNF-α, IL-13 and TWEAK/Fn14 synergistically contribute to theperpetuation and aggravation of intestinal inflammation, such as ulcerative colitis.

Research Products

• [Journal Article] TWEAK/Fn14 Pathway : a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis. (2009)
  • Author(s): Dohi T, Borodovsky A, Wu P, Shearstone JR, Kawashima R, Runkel L, Rajman L, Dong X, Scott ML, Michaelson JS, Jakubowski A, Burkly LC
  • Journal Title: Gastroenterology 136 Pages: 912-923
• [Journal Article] IL-13による腸管上皮の透過性亢進の機序
  • Author(s): 川島麗、土肥多惠子
  • Journal Title: 臨床免疫・アレルギー科 55巻2号 Pages: 229-233
• [Presentation] Effect of Combination Treatment With TNF-Inhibitor and Anti-TWEAK Antibody in Mouse Colitis Model. (2010)
  • Author(s): Dohi, T., Kawashima, R., Kawamura, Y., I., Michaelson, J., Burkly, L.C
  • Organizer: Digestive Disease Week 2010 Annual Meeting,poster
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20100000
• [Presentation] Multiple Functions of Glycoprotein 2 (Gp2) in the Gastrointestinal Systems ; A Link to Sorting, Packaging and Recycling of the Digestive Enzymes in the Exocrine Pancreas. (2010)
  • Author(s): Tokuhira, Y., Suzuki, R., Kawashima, R., Fukuoka, S.I
  • Organizer: Digestive Disease Week Annual Meeting,poster
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20100000
• [Presentation] Intraperitoneal Secretion of Cytokines and Chemokines in Response to the Surgical Stress. (2009)
  • Author(s): Kawashima, R., Kawamura, Y., I., Phongsisay, V., Okada, T., Toyama-Sorimachi, N., Kawamura Y., J., Konishi, F., Dohi, T
  • Organizer: Digestive Disease Week Annual Meeting, poster
  • Place of Presentation: Chicago, USA
  • Year and Date: 20090000
• [Presentation] Role of TWEAK (TNF-a-Like Weak Inducer of Apoptosis) in Intestinal Inflammation and Tissue Repair. (2009)
  • Author(s): Dohi,T., Kawashima,R., Burkly,L.C
  • Organizer: Digestive Disease Week Annual Meeting, poster
  • Place of Presentation: Chicago, USA
  • Year and Date: 20090000
• [Presentation] TWEAK/Fn14 pathway promotes intestinal epithelial cell apoptosis (2009)
  • Author(s): 川島麗、WU Ping、河村由紀、岡田俊彦、PHOGSISAY Vongsavanh、反町典子、BURKLY Linda C、土肥多恵子
  • Organizer: 第39回日本免疫学会総会,示説
  • Place of Presentation: 大阪
  • Year and Date: 20090000
• [Book] マッキー生化学第4版,化学同人,第一章訳者福岡伸一・川島麗 (2010)
  • Author(s): 市川厚監修、福岡伸一監訳
  • Total Pages: 801