2010 Fiscal Year Final Research Report
Role of the interaction of extracellular matrix with integrin in the cardiovascular disease
| Project/Area Number |
21790696
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
MATSUI Yutaka Hokkaido University, 遺伝子病制御研究所, 特任准教授 (30431381)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 分子心臓病態学 / 分子血管病態学 |
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| Research Abstract |
The interactions between extracellular matrix proteins and integrins play pivotal roles in the development of many cardiovascular diseases, including cardiac remodeling after myocardial infarction (MI) and atherosclerosis. We had two major novel findings as below. 1) Syndecan-4 and alpha9 integrin plays a critical role in the cardiac healing process after MI. 2) Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization.
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