2010 Fiscal Year Final Research Report

Elucidation of the basic mechanism of angiogenesis and cardiomyocyte regeneration induced by the external shockwaves.

Research Project

Project/Area Number	21790697
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Circulatory organs internal medicine
Research Institution	Tohoku University
Principal Investigator	TAKEDA Morihiko Tohoku University, 病院, 助教 (30375084)
Research Collaborator	HAO Kiyotaka 東北大学, 大学院・医学系研究科, 大学院生 KIKUCHI Yoku 東北大学, 大学院・医学系研究科, 大学院生
Project Period (FY)	2009 – 2010
Keywords	体外衝撃波治療法 / 血管新生 / 慢性心不全
Research Abstract	We demonstrated that the shockwave treatment applied to cultured human umbilical vein endothelial cells up-regulated mRNA expression of vascular endothelial growth factor, although further studies are required to determine the optimal condition of the shockwave treatment. Extracorporeal shockwave therapy applied to a rat experimental model of chronic heart failure induced a tendency to improve a left ventricular contractile function and a survival rate as well as a significant increase of capillary density in myocardium.

(2 results)