2010 Fiscal Year Final Research Report
Investigation of the intracellular signaling induced by the SUMO modification in the process of CHF
| Project/Area Number |
21790701
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Yamagata University |
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Principal Investigator |
SHISHIDO Tetsuro Yamagata University, 医学部, 助教 (60400545)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 慢性心不全 / 糖尿病 / SUMOylation |
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| Research Abstract |
Clarify the mechanisms by which aging and diabetes are independent factor for the advancing the heart failure after myocardial infarction contribute to find a new therapeutic target for chronic heart failure. As shown in previous reports using animal model, we found that oxidative stress is increased in patients with heart failure, moreover, its concentration is associated with the severity and prognosis. We found the important role of DGKalpha, which exist in human heart but not in mice, in the process of ischemia reperfusion injury. We also found that oxidative stress modulated the kinase cascade, and modulated the SUMOylation and ubiquitination, finally induced myocardial injury.
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[Journal Article] 8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event.2011
Author(s)
Suzuki S, Shishido T, Ishino M, Katoh S, Sasaki T, Nishiyama S, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Takeishi Y, Kubota I.
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Journal Title
Peer Reviewed
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[Journal Article] Iodine-123-metaiodobenzylguanidine imaging can predict future cardiac events in heart failure patients with preserved ejection fraction.2010
Author(s)
Katoh S, Shishido T, Kutsuzawa D, Arimoto T, Netsu S, Funayama A, Ishino M, Niizeki T, Nishiyama S, Takahashi H, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Kubota I.
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Journal Title
Ann Nucl Med. 24
Pages: 679-686
Peer Reviewed
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[Journal Article] Novel role of Cterminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction viaregulating ERK5-mediated degradation of inducible cAMP early repressor.2010
Author(s)
Woo CH, Le NT, Shishido T, Chang E, Lee H, Heo KS, Mickelsen DM, Lu Y, McClain C, Spangenberg T, Yan C, Molina CA, Yang J, Patterson C, Abe J.
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Journal Title
FASEB J. 24
Pages: 4917-4928
Peer Reviewed
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[Journal Article] Serum midkine as a predictor of cardiac events in patients with chronic heart failure.2010
Author(s)
Kitahara T, Shishido T, Suzuki S, Katoh S, Sasaki T, Ishino M, Nitobe J, Miyamoto T, Miyashita T, Watanabe T, Takeishi Y, Kubota I.
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Journal Title
J Card Fail. 16
Pages: 308-313
Peer Reviewed
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[Presentation] A comparison of B-type natriuretic peptide and heart-type fatty acid binding protein as predictors of cardiac events in heart failure patients with chronic kidney disease.2010
Author(s)
Ishino M, Shishido T, Funayama A, Netsu S, Kiribayashi N, Arimoto T, Takahashi H, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Kubota I
Organizer
American Heart Association Scientific Sessions 2010
Place of Presentation
Chicago
Year and Date
20101113-20101117
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[Presentation] Short-and long-term outcome and risk stratification by multibiomarkers in patients with chronic heart failure.2010
Author(s)
Ishino M, Shishido T, Funayama A, Netsu S, Kiribayashi N, Arimoto T, Takahashi H, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Kubota I
Organizer
American Heart Association Scientific Sessions 2010
Place of Presentation
Chicago
Year and Date
20101113-20101117
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[Presentation] Combination of pentosidine and carboxy-terminal telopeptide of type I collagen strongly predicts cardiac events in heart failure patients with preserved left ventricular ejection fraction.2010
Author(s)
Funayama A, Shishido T, Ohtaki Y, Hasegawa H, Honda S, Netsu S, Ishino M, Arimoto T, Takahashi H, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Kubota I
Organizer
American Heart Association Scientific Sessions 2010
Place of Presentation
Chicago
Year and Date
20101113-20101117
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[Presentation] Serum surfactant protein-D is a useful marker reflecting pulmonary congestion in patients with heart failure.2010
Author(s)
Netsu S, Shishido T, Ohtaki Y, Hasegawa H, Honda S, Funayama A, Ishino M, Arimoto T, Takahashi H, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Kubota I
Organizer
American Heart Association Scientific Sessions 2010
Place of Presentation
Chicago
Year and Date
20101113-20101117
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[Presentation] Heart-type fatty acid binding protein as predictor of cardiac mortality and events in patients with acute decompensated heart failure.2010
Author(s)
Ishino M, Shishido T, Funayama A, Netsu S, Kiribayashi N, Arimoto T, Takahashi H, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Kubota I
Organizer
American Heart Association Scientific Sessions 2010
Place of Presentation
Chicago
Year and Date
20101113-20101117
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[Presentation] Utility of urinary excretion of b2 microglobulin to identify high risk subset for restenosis in patients who underwent percutaneous coronary intervension.2010
Author(s)
Funayama A, Shishido T, Ohtaki Y, Hasegawa H, Honda S, Netsu S, Ishino M, Arimoto T, Takahashi H, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Kubota I
Organizer
American Heart Association Scientific Sessions 2010
Place of Presentation
Chicago
Year and Date
20100013-20101117
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