A role of muscle-restricted coiled-coil protein (MURC) in cardiac hypertrophy and heart failure

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790703
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: OGATA TAKEHIRO Kyoto Prefectural University of Medicine, 医学部附属病院, 専攻医 (10402877)
• Project Period (FY): 2009 – 2010
• Keywords: 筋特異的遺伝子 / 心肥大 / 心不全

Research Abstract

MURC expression was increased in cardiac hypertrophy and failing hearts. When MURC was overexpressed in CMs, MURC induced ERK activation and cardiomyocyte (CM) hypertrophy. shRNA-mediated MURC knockdown impaired α1 adrenergic agonist-induced CM hypertrophy and ERK activation. MURC-induced increases in cell size were attenuated by a MEK inhibitor. Furthermore, MURC bound to cavin family proteins (cavin-1, -2), caveolin-3, α1 adrenergic receptor, and p-ERK in CMs.

Research Products

• [Journal Article] PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes. (2010)
  • Author(s): Isodono K, Takahashi T, Imoto H, Nakanishi N, Ogata T, Asada S, Adachi A, Ueyama T, Oh H, Matsubara H.
  • Journal Title: PLoS One. 5(3) Pages: e9746
  • Peer Reviewed
• [Journal Article] MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. (2008)
  • Author(s): Ogata T, Ueyama T, Isodono K, Tagawa M, Takehara N, Kawashima T, Harada K, Takahashi T, Shioi T, Matsubara H, Oh H.
  • Journal Title: Mol Cell Biol. 28(10) Pages: 3424-3436
  • Peer Reviewed
• [Journal Article] MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis. (2008)
  • Author(s): Tagawa M, Ueyama T, Ogata T, Takehara N, Nakajima N, Isodono K, Asada S, Takahashi T, Matsubara H, Oh H.
  • Journal Title: AmJ Physiol Cell Physiol. 295(2) Pages: C490-8
  • Peer Reviewed
• [Presentation] MURC induces cardiomyocyte hypertrophy through the extracellular signal-regulated kinase pathway. (2010)
  • Author(s): Naito D, Ogata T, Amano K, Taniguchi T, Isodono K, Imoto H, Adachi A, Takahashi T, Ueyama T, Matsubara H.
  • Organizer: International Symposium on Cardiovascular Endocrinology and Metabolism
  • Place of Presentation: Nara, Japan
  • Year and Date: 20100100
• [Presentation] MURC, Muscle-restricted coiled-coil protein, regulates caveolae morphology and induces hypertrophy in cardiomyocytes. (2010)
  • Author(s): Taniguchi T, Ogata T, Naito D, Nakanishi N, Miyagawa K, Amano K, Isodono K, Imoto H, Tagawa M, Takehara N, Asada S, Adachi A, Morimoto M, Takahashi T, Oh H, Ueyama T, Matsubara H.
  • Organizer: AHA Scientific Sessions
  • Place of Presentation: Chicago IL. USA
  • Year and Date: 2010-11-17
• [Presentation] Cavin familyとしてのMURCの役割およびMURCの心筋疾患に及ぼす影響とメカニズムの検討 (2010)
  • Author(s): 中西直彦, 小形岳寛, 上山知己, 宮川浩太郎, 内藤大督, 谷口琢也, 松原弘明
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡,日本
  • Year and Date: 2010-10-15