2010 Fiscal Year Final Research Report
The relationship between protein levels and physiological parameters for cardiomyopathy
| Project/Area Number |
21790716
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
HIRASHIKI Akihiro Nagoya University, 医学部附属病院, 病院助教 (10418741)
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| Research Collaborator |
SAKAKIBARA Masaki 名古屋大学, 医学部附属病院・循環器内科, 医員
OHSHIMA Kei 名古屋大学, 医学部附属病院・循環器内科, 医員
OKUMURA Takahiro 名古屋大学, 大学院・医学系研究科・循環器内科学, 大学院
BANDO Yasuko 名古屋大学, 大学院・医学系研究科・循環器内科学, 助教
SEI Kenbu 名古屋大学, 大学院・医学系研究科・循環器内科学, 特任講師
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| Project Period (FY) |
2009 – 2010
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| Keywords | 慢性心不全 / 心筋特性 / 予後予測因子 / 心機能 |
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| Research Abstract |
To clarify pathophysiological mechanisms, we performed the pathophysiological analysis about the amounts of Ca-handling protein mRNAs levels and the hemodynamic parameters in patients with cardiomyopathy. In 2010, we reported that the relationship between dobutamine-induced mechanical alternans and mRNA levels of Ca-handling protein in patients with dilated cardiomyopathy. In 2009, Mitochondria showed functional impairment and morphological disorganization in the left ventricle of HCM patients. These mitochondrial changes were associated with impaired myocardial contractile and relaxation reserves.
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[Journal Article] Adiponectin acts as a positive indicator of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy.2010
Author(s)
Unno K, Shibata R, Izawa H, Hirashiki A, Murase Y, Yamada T, Kobayashi M, Noda A, Nagata K, Ouchi N, Murohara T.
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Journal Title
Heart. 96(5)(Epub 2009 Jul 30.)
Pages: 357-361
Peer Reviewed
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[Presentation] Relationship between myocardial contractile reserve measured by dobutamine stress testing and peak oxygen consumption in patients with idiopathic dilated cardiomyopathy.2010
Author(s)
Okumura T, Hirashiki A, Ohshima K, Sakakibara M, Funahashi H, Yuji K, Takeshita K, Cheng XW, Yamada S, Murohara T.
Organizer
World Congress of Cardiology Scientific Sessions 2010
Place of Presentation
Beijing, China, China National Convention Centre
Year and Date
20100616-20100619
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[Presentation] The Association Between Myocardial Contractile Reserve By Dobutamine Stress Testing And Cardiopulmonary Exercise Testing Variables In Patients With Idiopathic Dilated Cardiomyopathy.2009
Author(s)
Okumura T, Hirashiki A, Ohshima K, Sakakibara M, Funahashi H, Ohshima Satoru, Kono Y, Takeshita K, Izawa H, Yamada S, Yokota M, Murohara T.
Organizer
American Heart Association, 82th Scientific Sessions 2009
Place of Presentation
Orland, America, Orange County Convention Center
Year and Date
20091115-20091118
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[Presentation] Diabetes mellitus is associated with impairment of myocardial relaxation and accumulation of collagen in patients with dilated cardiomyopathy.2009
Author(s)
Sakakibara M, Hirashiki A, Cheng XW, Bando Y, Ohshima K, Okumura T, Funahashi H, Ohshima S, Noda A, Izawa H, Murohara T.
Organizer
American Heart Association, 82th Scientific Session 2009
Place of Presentation
Orland, America, Orange County Convention Center
Year and Date
20091115-20091118
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[Remarks] ホームページ等
