• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

The molecular mechanism focused on calcium in pathogenesis of heart failure and its clinical application.

Research Project

  • PDF
Project/Area Number 21790723
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionOsaka University

Principal Investigator

TAKEDA Toshihiro  Osaka University, 医学部附属病院, 医員 (70506493)

Project Period (FY) 2009 – 2010
Keywords分子心臓病態学 / カルシウム / 興奮収縮連関 / ノックアウトマウス
Research Abstract

In the heart, calcium plays important roles in excitation-contraction (E-C) coupling. SERCA2a and ryanodine receptor (RyR2) are two major Ca^<2+> signaling proteins involving in E-C coupling. The activity of these proteins is regulated by their accessory proteins, which may play an important role in the pathogenesis of heart failure. Sorcin is the one of the protein that is associated with RyR2
The expression level of sorcin was altered in remodeling hearts. In order to elucidate a role of sorcin in the heart, we generated sorcin knockout mice. The mice showed no abnormal E-C coupling.

  • Research Products

    (7 results)

All 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (3 results)

  • [Journal Article] Inhibition of autophagy in the heart induces age-related cardiomyopathy.2010

    • Author(s)
      Taneike M, Yamaguchi O, Nakai A, Hikoso S, Takeda T, et al.
    • Journal Title

      Autophagy 6

    • Peer Reviewed
  • [Journal Article] Inhibition of phospholamban phosphorylation by O-GlcNAcylation : implications for diabetic cardiomyopathy.2010

    • Author(s)
      Yokoe S, Asahi M, Takeda T, Otsu K, et al.
    • Journal Title

      Glycobiology 20

      Pages: 217-1226

    • Peer Reviewed
  • [Journal Article] Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure.2010

    • Author(s)
      Mizote I, Yamaguchi O, Hikoso S, Takeda T, et al.
    • Journal Title

      Journal of Molecular and Cellular Cardiology 48

      Pages: 302-309

    • Peer Reviewed
  • [Journal Article] The I・B kinase ・/nuclear factor ・B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression.2010

    • Author(s)
      Hikoso S, Yamaguchi O, Nakano Y, Takeda T, et al.
    • Journal Title

      Circulation Research 105

      Pages: 70-79

    • Peer Reviewed
  • [Presentation] Allosteric Modulation of Hemoglobin is the New Therapeutic Target for Improving Exercise Capacity in Patients with Chronic Heart Failure.2009

    • Author(s)
      武田理宏
    • Organizer
      第26回国際心臓研究学会日本部会
    • Place of Presentation
      札幌
    • Year and Date
      2009-12-05
  • [Presentation] ヘモグロビン酸素親和性に着目した心不全患者運動耐容能改善の試み2009

    • Author(s)
      武田理宏
    • Organizer
      第13回日本心血管内分泌代謝学会
    • Place of Presentation
      大宮
    • Year and Date
      2009-10-23
  • [Presentation] Reduction in Hemoglobin-Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice with Chronic Heart Failure.2009

    • Author(s)
      武田理宏
    • Organizer
      第36回国際生理学会世界大会
    • Place of Presentation
      京都
    • Year and Date
      2009-07-30

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi