2010 Fiscal Year Final Research Report
Association Between Modifier Gene Polymorphisms and Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy
| Project/Area Number |
21790728
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Ehime University |
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Principal Investigator |
OGIMOTO Akiyoshi Ehime University, 医学部附属病院, 講師 (00403832)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 臨床心血管病態学 / 肥大型心筋症 / 遺伝子多型 / 予後 |
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| Research Abstract |
The aim of this study was to investigate the pharmacogenetic interactions and the association between modifier gene polymorphisms and cardiovascular events in patients with hypertrophic cardiomyopathy (HCM). Obstructive HCM patients with the angiotensin-converting enzyme (ACE) D allele had a high left ventricular pressure gradient. Cibenzoline was more effective in obstructive HCM patients with the ACE D allele. In addition, a common genetic variant (rs632793) in the NPPB gene was found to be associated with circulating BNP concentrations and cardiovascular events in patients with HCM.
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[Journal Article] Myocardial fibrosis attenuates the effect of cibenzoline on left ventricular diastolic function in patients with hypertrophic cardiomyopathy.2010
Author(s)
Saito M, Okayama H, Yoshii T, Hiasa G, Sumimoto T, Inaba S, Nishimura K, Inoue K, Ogimoto A, Shigematsu Y, Funada JI, Hamada M, Higaki J.
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Journal Title
J Cardiovasc Pharmacol Epub ahead of print
Peer Reviewed
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[Journal Article] The differences in left ventricular torsional behavior between patients with hypertrophic cardiomyopathy and hypertensive heart disease.2010
Author(s)
Saito M, Okayama H, Yoshii T, Hiasa G, Sumimoto T, Inaba S, Nishimura K, Inoue K, Ogimoto A, Ohtsuka T, Funada JI, Shigematsu Y, Higaki J.
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Journal Title
Int J Cardiol Epub ahead of print
Peer Reviewed
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[Journal Article] Pharmacogenetic interactions between angiotensin-converting enzyme insertion/deletion polymorphism and response to cibenzoline in patients with hypertrophic obstructive cardiomyopathy.2010
Author(s)
Ogimoto A, Okayama H, Nagai T, Ohtsuka T, Suzuki J, Inoue K, Nishimura K, Saito M, Shigematsu Y, Hamada M, Miki T, Higaki J.
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Journal Title
J Cardiovasc Pharmacol 55
Pages: 506-510
Peer Reviewed
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[Journal Article] Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy.2009
Author(s)
Ogimoto A, Okayama H, Nagai T, Ohtsuka T, Suzuki J, Inoue K, Nishimura K, Shigematsu Y, Tabara Y, Kohara K, Miki T, Higaki J.
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Journal Title
J Cardiol 54
Pages: 66-70
Peer Reviewed
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