2010 Fiscal Year Final Research Report
Development of a Novel Minimally Invasive Therapy Based on Pulse-infusion DDS Catheter for Coronary Arterial Diseases
Project/Area Number |
21790732
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Kyushu University |
Principal Investigator |
NAKANO Kaku Kyushu University, 大学院・医学研究院, 学術研究員 (30420607)
|
Project Period (FY) |
2009 – 2010
|
Keywords | 分子血管病態学 / プラーク破綻 / マクロファージ / ナノ粒子 |
Research Abstract |
We developed bio-absorbable nanoparticles which has efficacy drug delivery system. Furthermore, fluorescent marker incorporated nanoparticles were administrated into balloon injured rabbit and porcine coronary arteries using an infusion catheter system. Nanoparticles were observed and retentive until up to 28 days. Drug incorporated nanoparticles significantly attenuated neointimal formation as compared with vehicle control group.
|
-
-
[Journal Article] Nanoparticle-Mediated Delivery of Pitavastatin Into Lungs Ameliorates the Development and Induces Regression of Monocrotaline-Induced Pulmonary Artery Hypertension.2010
Author(s)
Chen L, Nakano K, Kimura S, Matoba T, Iwata E, Miyagawa M, Tsujimoto H, Nagaoka K, Kishimoto J, Sunagawa K, Egashira K
-
Journal Title
Hypertension. 57(2)
Pages: 343-350
-
[Journal Article] Nanoparticle-Mediated Delivery of Nuclear FactorκB Decoy Into Lungs Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension.2009
Author(s)
Kimura S, Egashira K, Chen L, Nakano K, Iwata E, Miyagawa M, Tsujimoto H, Hara K, Morishita R, Sueishi K, Tominaga R, Sunagawa K
-
Journal Title
Hypertension. 53(5)
Pages: 877-883
-
[Journal Article] Formulation of nanoparticle-eluting stents by a cationic electrodeposit coating technology: Efficient and safe nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries.2009
Author(s)
Nakano K, Egashira K, Masuda S, Funakoshi K, Zhao G, Kimura S, Matoba T, Sueishi K, Endo Y, Kawashima Y, Hara K, Tsujimoto H, Tominaga R, Sunagawa K
-
Journal Title
J Am Coll Cardiol : Cardovasular Intervention. 2(4)
Pages: 277-283
-
[Journal Article] Therapeutic Neovascularization by Nanotechnology-Mediated Cell-Selective Delivery of Pitavastatin into the Vascular Endothelium.2009
Author(s)
Kubo M, Egashira K, Inoue T, Koga J, Oda S, Chen L, Nakano K, Matoba T, Kawashima Y, Hara K, Tsujimoto H, Sueishi K, Tominaga R, Sunagawa K
-
Journal Title
Atheroscler Thromb Vasc Biol. 29
Pages: 796-801
-
-
-
-
-
-
-
[Presentation] Formulation of nanoparticle-eluting stents by a cationic electrodeposit coating technology: Efficient and safe nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries2009
Author(s)
Nakano K, Egashira K, Masuda S, Funakoshi K, Zhao G, Kimura S, Matoba T, Sueishi K, Endo Y, Kawashima Y, Hara K, Tsujimoto H, Tominaga R, Sunagawa K
Organizer
第41回日本動脈硬化学会
Place of Presentation
山口
Year and Date
2009-07-17
-
-
-