2010 Fiscal Year Final Research Report
Development of new therapy to prevent plaque destabilization and rupture by regulating macrophage polarity
| Project/Area Number |
21790734
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
MATOBA Tetsuya Kyushu University, 大学病院, 助教 (20448426)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 分子血管病態学 / プラーク破綻 / マクロファージ / ナノ粒子 |
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| Research Abstract |
Activated (M1) macrophage plays a primary role in atherosclerotic plaque destabilization and rupture. The author hypothesized that regulating macrophage M1/M2 polarity toward anti-inflammatory M2 enable to prevent atherosclerotic plaque destabilization and rupture. In ApoE-KO mice, nanoparticle-mediated monocyte-selective treatment with PPAR-gamma agonist inhibited macrophage M1 shift, and reduced incidence of plaque rupture in the brachiocephalic arteries. These results proved the concept of a new therapy for preventing plaque rupture, by regulating macrophage polarity.
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[Journal Article] Nanoparticle-Mediated Delivery of Pitavastatin Into Lungs Ameliorates the Development and Induces Regression of Monocrotaline-Induced Pulmonary Artery Hypertension.2011
Author(s)
Chen L, Nakano K, Kimura S, Matoba T, Iwata E, Miyagawa M, Tsujimoto H, Nagaoka K, Kishimoto J, Sunagawa K, Egashira K
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Journal Title
Hypertension 57(2)
Pages: 343-350
Peer Reviewed
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