2011 Fiscal Year Final Research Report
Utility of adaptive servo ventilation for chronic heart failure with sleep apnea syndrome
| Project/Area Number |
21790737
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 心不全 / 睡眠時無呼吸症候群 / チェーン・ストークス呼吸 / adaptive servo ventilation / 酸素療法 / MIBG心筋シンチ / BNP / 呼吸補助療法 |
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| Research Abstract |
Chronic heart failure(CHF) is a prevalent syndrome with poor prognosis, especially the major cause of death and re-hospitalization in the elderly, and secondary prevention is important. Identification of factors that contribute to increased mortality might lead to the development of a new strategy to improve survival of CHF. It has been reported that about 50% of CHF patients have sleep apnea syndrome(SAS), which consists of obstructive sleep apnea(OSA) and Cheyne-Stokes respiration(CSR). Adaptive servo ventilation(ASV) is a ventilator support system specifically designed to normalize ventilation in patients with CSR and OSA. ASV can regulate the airway ventilation volume according to the demand based on the variable tidal volume throughout the period of CSR. It has been reported that ASV can improve not only SAS but also cardiac function. We demonstrate that short and long term effects of ASV on heart failure with CSR. Adaptive servo ventilation might be a promising useful tool for chronic heart failure as an important non-pharmacotherapy.
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[Journal Article] A single night' beneficial impacts of adaptive servo ventilation on cardiac overload, sympathetic nervous activity, and myocardial damage in patients with chronic heart failure and sleep disordered breathing2012
Author(s)
Yoshihisa A, Suzuki S, Miyata M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
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Journal Title
Peer Reviewed
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[Journal Article] Adaptive servo ventilation improves Cheyne-Stokes respiration, cardiac function and prognosis in chronic heart failure patients with cardiac resynchronization therapy2012
Author(s)
Miyata M, Yoshihisa A, Suzuki S, Yamada S, Kamioka M, Kamiyama Y, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y. Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
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Journal Title
Peer Reviewed
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[Journal Article] Adaptive servo ventilation improves cardiac dysfunction and prognosis in chronic heart failure patients with Cheyne-Stokes respiration2011
Author(s)
Yoshihisa A, Shimizu T, Owada T, Nakamura Y, Iwaya S, Yamauchi H, Miyata M, Hoshino Y, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
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Journal Title
Int Heart J
Volume: 52
Pages: 218-223
Peer Reviewed
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[Journal Article] 不完全型房室中隔欠損症の術後約30年でdiscrete subaortic stenosisをきたした1症例2010
Author(s)
義久精臣, 杉本浩一, 三阪智史, 安藤勝也, 佐藤崇匡, 金城貴士, 小林淳, 國井浩行, 高野真澄, 斎藤修一, 石橋敏幸, 若松大樹, 佐戸川弘之, 横山斉, 竹石恭知
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Journal Title
心臓
Volume: 42
Pages: 1072-1078
Peer Reviewed
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[Journal Article] 非心臓手術周術期に遅発性ステント血栓症を発症した1例2010
Author(s)
三阪智史, 中里和彦, 水上浩行, 安藤勝也, 待井宏文, 義久精臣, 坂本信雄, 泉田次郎, 國井浩行, 斎藤修一, 石橋敏幸, 竹石恭知
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Journal Title
心臓
Volume: 42
Pages: 1059-1065
Peer Reviewed
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[Journal Article] Flow-mediated dilatation identifies impaired endothelial function in patients with sleep apnea syndrome2010
Author(s)
Yoshihisa A, Owada T, Hoshino Y, Miyata M, Misaka T, Sato T, Suzuki S, Sakamoto N, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishibashi T, Takeishi Y.
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Journal Title
Fukushima J Med Sci
Volume: 56
Pages: 115-120
Peer Reviewed
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[Journal Article] 心原性脾塞栓症による脾破裂を合併した感染性心内膜炎の1例2009
Author(s)
義久精臣, 宮田真希子, 半田裕子, 三阪智史, 水上浩行, 山田慎哉, 高橋裕志, 安藤勝也, 佐藤崇匡, 待井宏文, 金城貴士, 上北洋徳, 國井浩行, 斎藤修一, 石橋敏幸, 鈴木理, 竹石恭知
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Journal Title
心臓
Volume: 41
Pages: 422-429
Peer Reviewed
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[Presentation] Acute benefical effects of adaptive servo ventilation on cardiac function In chronic heart failure patients with Cheyne-Stokes respiration2012
Author(s)
Yoshihisa A, Suzuki S, Miyata M, Satoh T, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
Organizer
第76回日本循環器学会学術集会
Place of Presentation
福岡
Year and Date
20120316-0318
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[Presentation] Sleep Apnea Syndrome Including Cheyne-Stokes Respiration Remains after Cardiac Resynchronization Therapy2012
Author(s)
Yoshihisa A, Suzuki S, Miyata M, Satoh T, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
Organizer
第76回日本循環器学会学術集会
Place of Presentation
福岡
Year and Date
20120316-0318
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[Presentation] Adaptive servo ventilation improves cardio-renal function and prognosis in heart failure with chronic kidney disease and sleep apnea syndrome2012
Author(s)
Yoshihisa A, Suzuki S, Miyata M, Satoh T, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
Organizer
第76回日本循環器学会学術集会
Place of Presentation
福岡
Year and Date
20120316-0318
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[Presentation] Overnight use of adaptive servo ventilation reduces cardiac overload and improves renal function in heart failure patietnts with Cheyne-Stokes respiration2012
Author(s)
Yoshihisa A, Suzuki S, Miyata M, Satoh T, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
Organizer
第76回日本循環器学会学術集会
Place of Presentation
福岡
Year and Date
20120316-0318
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[Presentation] Overnight use of adaptive servo ventilation attenuates daily sympathetic nervous activity : Report from heart rate variavility by wireless Holter ECG2012
Author(s)
Yoshihisa A, Suzuki S, Miyata M, Satoh T, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
Organizer
第76回日本循環器学会学術集会
Place of Presentation
福岡
Year and Date
20120316-0318
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[Presentation] Overnight use of adaptive servo ventilation reduces cardiac overload and improves renal function in patients with chronic heart failure and Cheyne-Stokes respiration2011
Author(s)
Yoshihisa A, Suzuki S, Miyata M, Sato T, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitho S, Takeishi Y.
Organizer
Scientific Sessions of American Heart Association
Place of Presentation
Orlando, Florida USA
Year and Date
20111112-1116
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[Presentation] Adaptive servo ventilation improves cardiac function and long term prognosis in heart failure patients with Cheyne-Stokes respiration2011
Author(s)
Yoshihisa A, Miyata M, Sato T, Suzuki S, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
Organizer
Congress of the European Society of Cardiology
Place of Presentation
Paris, France
Year and Date
20110827-0831
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[Presentation] Non-invasive detection of vascular dysfunction in sleep apnea syndrome by cardio-ankle vascular index and flow-mediated dilatation2011
Author(s)
Yoshihisa A, Miyata M, Sato T, Suzuki S, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
Organizer
Congress of the European Society of Cardiology
Place of Presentation
Paris, France
Year and Date
20110827-0831
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[Presentation] Adaptive servo ventilation improves cardiac dysfunction and prognosis in heart failure patients with Cheyne-Stokes respiration2011
Author(s)
Yoshihisa A, Shimizu T, Owada T, Misaka T, Sato T, Suzuki S, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
Organizer
第75回日本循環器学会学術集会
Place of Presentation
横浜
Year and Date
20110803-0804
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[Presentation] Adaptive servo ventilation improves cardiac function and prognosis in heart failure patients with Cheyne-Stokes respiration2010
Author(s)
Yoshihisa A, Sato T, Suzuki S, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y.
Organizer
Scientific Sessions of American Heart Association
Place of Presentation
Chicago, Illinois, USA
Year and Date
20101113-1117
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[Presentation] 心不全に合併するチェーンストーク呼吸の重症度:123I-MIBG心筋シンチによる心臓交感神経機能の検討2010
Author(s)
義久精臣, 大和田卓史, 佐藤崇匡, 鈴木聡, 杉本浩一, 國井浩行, 中里和彦, 鈴木均, 斎藤修一, 石橋敏幸, 竹石恭知
Organizer
第58回日本心臓病学会学術集会
Place of Presentation
東京
Year and Date
20100917-0919
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[Presentation] チェーン・ストーク呼吸(CSR)合併心不全患者におけるadaptive servo ventilation及び酸素療法の交感神経活性に対する効果の検討2010
Author(s)
義久精臣, 大和田卓史, 佐藤崇匡, 鈴木聡, 杉本浩一, 國井浩行, 中里和彦, 鈴木均, 斎藤修一, 石橋敏幸, 竹石恭知
Organizer
第58回日本心臓病学会学術集会
Place of Presentation
東京
Year and Date
20100917-0919
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[Presentation] β遮断薬や心臓再同期療法にてCheyne-Stokes呼吸の加療は不要となるか?2010
Author(s)
義久精臣, 大和田卓史, 佐藤崇匡, 鈴木聡, 杉本浩一, 國井浩行, 中里和彦, 鈴木均, 斎藤修一, 石橋敏幸, 竹石恭知
Organizer
第58回日本心臓病学会学術集会
Place of Presentation
東京
Year and Date
20100917-0919
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