2011 Fiscal Year Final Research Report
Fortilin, a novel p53 inhibiting protein, in cardiovascular system.
| Project/Area Number |
21790738
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 分子心臓病態学 |
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| Research Abstract |
Fortilin overexpression preserves cardiac function in mice model of heart failure. Recent studies indicate that p53 promotes the deterioration of cardiac function. Fortilin is a novel p53 inhibiting protein. In this study, we generated Fortilin transgenic mice that overexpress Fortilin in the hearts. The anthracycline chemotherapy agent developed more severe heart failure in control mice than the Fortilin transgenic mice. These data suggest that Fortilin overexpression may induce preferable effects on cardiac function in heart failure.
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