2010 Fiscal Year Final Research Report
Development of HDL-raising drugs targeting ABCA1
| Project/Area Number |
21790739
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya City University |
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Principal Investigator |
IWAMOTO Noriyuki Nagoya City University, 大学院・医学研究科, 研究員 (70534709)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ABCA1 / コレステロール / HDL / PKC / AP2 / カルモジュリン / カルパイン / アポリポプロテイン |
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| Research Abstract |
ABCA1 expression is regulated negatively by a transcriptional factor AP2 and its protein level is modulated by calpain-mediated proteolytic degradation. In this research project, I demonstrated that regulation of the ABCA1 gene by AP2 is mediated by its phosphorylation by PKD, which is similar to negative regulation of the adiponectin gene. I also showed that calmodulin binds ABCA1 and suppress its calpain-mediated degradation. A calmodulin inhibitor W7 enhanced calmodulin binding to ABCA1 to increase HDL biogenesis.
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Research Products
(7 results)
