The role of c-Abl in cardiac hypertrophy signaling pathway

2011 Fiscal Year Final Research Report

• Project/Area Number: 21790744
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kitasato University
• Principal Investigator: TOJO Taiki 北里大学, 医学部, 講師 (70327344)
• Project Period (FY): 2009 – 2011
• Keywords: 心肥大 / アンジオテンシンII

Research Abstract

We investigated the role of c-Abl in a cardiomyocyte hypertrophy signaling on cardiac remodeling in response to angiotensin II provocation. The cAbl may be an important modulator for Angiotensin II induced cardiac hypertrophy, and further investigations were needed.

Research Products

• [Journal Article] Circulating interleukin-18 : a specific biomarker for atherosclerosis-prone patients with metabolic syndrome (2011)
  • Author(s): Yamaoka-Tojo M, Tojo T, Takahira N, Masuda T, Kameda R, Wakaume K, Izumi T.
  • Journal Title: Nutr Metab Volume: 8 Pages: 3
  • Peer Reviewed
• [Journal Article] JCADII Investigators. Intensively lowering both low-density lipoprotein cholesterol and blood pressure does not reduce cardiovascular risk in Japanese coronary artery disease patients. (2011)
  • Author(s): Kohro T, Yamazaki T, Izumi T, Daida H, Kurabayashi M, Miyauchi K, Tojo T, Nagai R
  • Journal Title: Circ J. Volume: 75(9) Pages: 2062-2070
• [Journal Article] Ezetimibe and reactive oxygen species (2011)
  • Author(s): Yamaoka-Tojo M, Tojo T, Takahira N, Masuda T, Izumi T.
  • Journal Title: Curr Vasc Pharmacol Volume: 9(1) Pages: 109-20
  • Peer Reviewed
• [Journal Article] Elevated circulating levels of an incretin hormone, glucagon-like peptide-1, are associated with metabolic components in high-risk patients with cardiovascular disease (2010)
  • Author(s): Yamaoka-Tojo M, Tojo T, Takahira N, Matsunaga A, Aoyama N, Masuda T, Izumi T.
  • Journal Title: Cardiovascular Diabetology Volume: 9 Pages: 17
  • Peer Reviewed
• [Journal Article] Effects of ezetimibe add-on therapy for high-risk patients with dyslipidemia (2009)
  • Author(s): Yamaoka-Tojo M, Tojo T, Kosugi R, Hatakeyama Y, Yoshida Y, Machida Y, Aoyama N, Masuda T, Izumi T.
  • Journal Title: Lipids in Health and Disease Volume: 8 Pages: 41
• [Presentation] Salusin-・is a novel diagnostic biomarker of neutrally mediated syncope (2012)
  • Author(s): Kameda R, Yamaoka-Tojo M, Tojo T, Wakaume K, Nemoto S, Kitasato L, Shichiri M, Izumi T.
  • Organizer: The 76th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Fukuoka
  • Year and Date: 2012-03-17
• [Presentation] Effects of increasing physical activity on circulating levels of Tenascin-C in high risk patients with atherosclerosis (2012)
  • Author(s): Kitasato L, Yamaoka-Tojo M, Kameda R, Wakaume K, Nemoto S, Shimohama T, Tojo T, Izumi T.
  • Organizer: The 76th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Fukuoka
  • Year and Date: 2012-03-16
• [Presentation] The change of circulating interleukin-18 is associated with the change of arteriosclerosis, a 5-year observational study from Kitasato Registry of Cardiovascular Disease Prevention (2011)
  • Author(s): Kameda R, Yamaoka-Tojo M, Wakaume K, Tojo T, Aiba N, Yoshida Y, Machida Y, Matsunaga A, Masuda T, Izumi T.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Yokohama
  • Year and Date: 20110000
• [Presentation] Soluble Fms-Like Tyrosine Kinase 1 is a novel predictor of cardiovascular disease progression in patients with coronary artery disease (2011)
  • Author(s): Kameda R, Yamaoka-Tojo M, Tojo T, Wakaume K, Nemoto S, Kitasato L, Yoshida Y, Shimohama T, Machida Y, Izumi T.
  • Place of Presentation: USA
  • Year and Date: 2011-11-15
• [Presentation] Association between Pentraxin 3 and renal function in patients at high risk of cardiovascular disease (2011)
  • Author(s): Kameda R, Yamaoka-Tojo M, Tojo T, Wakaume K, Nemoto S, Kitasato L, Yoshida Y, Hatakeyama Y, Machida Y, Izumi T.
  • Organizer: The 15th Annual Scientific Meeting of Japanese Heart Failure Society
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2011-10-13
• [Presentation] Increased physical activity decreases circulating pentraxin 3 levels in patients at high risk of cardiovascular disease (2011)
  • Author(s): Wakaume K, Yamaoka-Tojo M, Nemoto S, Kameda R, Aiba N, Tojo T, Yoshida Y, Machida Y, Masuda T, Izumi T.
  • Organizer: ESC 2011
  • Place of Presentation: Paris, France
  • Year and Date: 2011-08-29
• [Presentation] The plasma levels of B-type natriuretic peptide is a useful predictor of cardiac events for out-clinic patients with asymptomatic heart failure who are in stable condition (2011)
  • Author(s): Yamaoka-Tojo M, Kitasato L, Nemoto S, Wakaume K, Kameda R, Yoshida Y, Machida Y, Tojo T, Kasuda T, Izumi T.
  • Organizer: ESC 2011
  • Place of Presentation: Paris, France
  • Year and Date: 2011-08-29
• [Presentation] Lifestyle modification-improving systemic athero-protective factor, circulating pentraxin 3, in high-risk patients with metabolic syndrome (2010)
  • Author(s): Yamaoka-Tojo M, Tojo T, Wakaume K, Kameda R, Takahira N, Aoyama N, Matsunaga A, Masuda T, Izumi T.
  • Organizer: AHA2010
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2010-11-15
• [Presentation] Anti-inflammatory effects of pentraxin 3 in human visceral adipocytes by reducing reactive oxygen species production (2010)
  • Author(s): Yamaoka-Tojo M, Tojo T, Takahira N, Aoyama N, Masuda T, Izumi T.
  • Organizer: ESC2010
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-08-30
• [Book] エビデンスにもとづく循環器病予防医学,疾病管理としての循環器予防医学、11肥満 (2012)
  • Author(s): 東條美奈子、東條大輝
  • Total Pages: 198-204
  • Publisher: 南山堂