2010 Fiscal Year Final Research Report

Epigenetic analysis and establishment of novel therapy for heart failure

Research Project

Project/Area Number	21790747
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Circulatory organs internal medicine
Research Institution	Keio University
Principal Investigator	KANEDA Ruri Keio University, 医学部, 助教 (70465029)
Research Collaborator	ONO Tomohiko 慶應義塾大学, 医学部, 研究員(非常勤) (80571249) NISHIYAMA Takahiko 慶應義塾大学, 医学部, 助教 (20464844)
Project Period (FY)	2009 – 2010
Keywords	心不全 / エピジェネティクス / ヒストン修飾酵素阻害薬
Research Abstract	We previously identified heart failure-specific epigenetic marks, trimethylation of histone H3 on lysine-4 (K4TM) or lysine-9 (K9TM) with using ChIP-on-chip analysis on the left ventricular cardiomyocytes of Dahl salt-sensitive rats which are genetically intolerant to excessive salt intake. In this project, we investigated whether administering an inhibitor of histone modifying enzyme which affects the trimethylation status on H3K9 ameliorates left ventricular dysfunction or not. Left ventricular contraction at failing stage has restored by administration of an inhibitor of H3K9 methyltransferase, Chaetocin. The inhibitor had a tendency to prolong survival term of animals. The intervention for heart failure-specific epigenetic alteration might become a novel therapeutic strategy for heart failure.

(3 results)