2010 Fiscal Year Final Research Report
Molecular and electrophysiological analysis of fatal arrhythmias
| Project/Area Number |
21790749
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
AIZAWA Yoshiyasu Keio University, 医学部, 助教 (20528145)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 遺伝性不整脈 / イオンチャネル / 心房細動 / 変異 / パッチクランプ法 |
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| Research Abstract |
We collected blood samples of the patients with familial atrial fibrillation after obtained written informed consent. So far, six pedigrees including four familial and two younger cases were included. Of those pedigrees, one patient suffered from atrial fibrillation from their thirties. He has the history of the catheter ablation for atrial fibrillation previously. He has the family history of atrial fibrillation of his brother and his father. The DNA was sequenced for KCNQ1, KCNH2, SCN5A, KCNE1, KCNE2, KCNJ2, and the CACNA1C.
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[Journal Article] J-RHYTHM Investigators. Comparison of antiarrhythmics used in patients with paroxysmal atrial fibrillation : subanalysis of J-RHYTHM Study.2010
Author(s)
Aizawa Y, Kohsaka S, Suzuki S, Atarashi H, Kamakura S, Sakurai M, Nakaya H, Fukatani M, Mitamura H, Yamazaki T, Yamashita T, Ogawa S
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Journal Title
Circ J. 74(1) Epub 2009.
Pages: 71-76
Peer Reviewed
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[Remarks] ホームページ等
