2011 Fiscal Year Final Research Report
monocyte・macrophage insulin resistance and atherosclerosis
| Project/Area Number |
21790752
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
MITA Tomoya 順天堂大学, 医学部, 助教 (90532557)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 単球-内皮相互作用 |
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| Research Abstract |
Insulin resistance is a risk factor for the progression of atherosclerosis, but its underlying mechanism has not fully addressed. We demonstrated that systemic and macrophage reduced insulin signal increased macrophage accumulation in the vascular walls with the increased expression of inflammatory mediators in thoracic aorta and macrophage attached to thoracic in mice.
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