2010 Fiscal Year Final Research Report
The explore of the underlying molecular mechanisms of cardiac repair in cell sheet transplantation-mediated improvement of cardiac function
| Project/Area Number |
21790754
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
MATSUURA Katsuhisa Tokyo Women's Medical University, 医学部, 講師 (70433993)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 細胞シート / 心筋前駆細胞 / パラクライン効果 |
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| Research Abstract |
When cardiac Sca-1 positive cells were isolated from the adult murine heart and were transplanted to infarcted heart as cell sheet, significant improvement of cardiac function was observed. Soluble form of VCAM-1 secreted from Sca-1 positive cells enhanced angiogenesis, cardioprotection, and migration of Sca-1 positive cells, which contributed to the improvement of cardiac function after cell sheet transplantation.
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Research Products
(8 results)
