• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

Development of new vascular regenerative therapy by replacement of bone marrow cells with pluripotent stem cell-derived vascular progenitor cells.

Research Project

  • PDF
Project/Area Number 21790757
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

YAMAHARA Kenichi  独立行政法人国立循環器病研究センター, 再生医療部, 室長 (50450888)

Co-Investigator(Renkei-kenkyūsha) ITOH Hiroshi  慶應義塾大学, 医学部・腎臓内分泌代謝内科, 教授 (40252457)
HOMMA Koichiro  慶応義塾大学, 医学部・腎臓内分泌代謝内科, 助教
Project Period (FY) 2009 – 2010
KeywordsES細胞 / マイクロRNA(miRNA) / 血管内皮細胞 / 血管平滑筋細胞 / 血管前駆細胞
Research Abstract

We examined the therapeutic potential of ES cell-derived vascular progenitor cells as the alternative of bone marrow-derived vascular progenitor cells. Although human ES cell-derived vascular smooth muscle cells (VSMCs) obtained by our original method were at a rather immature state of differentiation, induction of miR-145 resulted in fully differentiated VSMCs. We also found that human ES-derived VSMCs at early passage possessed high proliferation and migration property, which might be a suitable cell source for vascular regeneration.

  • Research Products

    (10 results)

All 2010 2009 2008 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Allogeneic administration of fetal membrane-derived mesenchymal stem cells attenuates acute myocarditis in rats.2010

    • Author(s)
      Ishikane S, Yamahara K, Sada M, Harada K, Kodama M, Ishibashi-Ueda H, Hayakawa K, Mishima K, Iwasaki K, Fujiwara M, Kangawa K, Ikeda T.
    • Journal Title

      J Mol Cell Cardiol. 49(5)

      Pages: 753-61

    • Peer Reviewed
  • [Journal Article] Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells.2010

    • Author(s)
      Homma K, Sone M, Taura D, Yamahara K, Suzuki Y, Takahashi K, Sonoyama T, Inuzuka M, Fukunaga Y, Tamura N, Itoh H, Yamanaka S, Nakao K.
    • Journal Title

      Atherosclerosis. 212(1)

      Pages: 42-7

    • Peer Reviewed
  • [Journal Article] Angiogenic properties of sustained release platelet-rich plasma: characterization in-vitro and in the ischemic hind limb of the mouse.2009

    • Author(s)
      Bir SC, Esaki J, Marui A, Yamahara K, Tsubota H, Ikeda T, Sakata R.
    • Journal Title

      J Vasc Surg. 50(4)

      Pages: 870-879.e2.

    • Peer Reviewed
  • [Journal Article] Impaired recovery of blood flow after hind-limb ischemia in mice lacking guanylyl cyclase-A, a receptor for atrial and brain natriuretic peptides.2009

    • Author(s)
      Tokudome T, Kishimoto I, Yamahara K, Osaki T, Minamino N, Horio T, Sawai K, Kawano Y, Miyazato M, Sata M, Kohno M, Nakao K, Kangawa K.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 29(10)

      Pages: 1516-21

    • Peer Reviewed
  • [Journal Article] Potential use of endothelial progenitor cells for regeneration of the vasculature.2009

    • Author(s)
      Yamahara K, Itoh H.
    • Journal Title

      Ther Adv Cardiovasc Dis 3(1)

      Pages: 17-27

    • Peer Reviewed
  • [Journal Article] Pathological role of angiostatin in heart failure : an endogenous inhibitor of mesenchymal stem-cell activation.2009

    • Author(s)
      Yamahara K, Min KD, Tomoike H, Kangawa K, Kitamura S, Nagaya N.
    • Journal Title

      Heart. 95(4)

      Pages: 283-9

    • Peer Reviewed
  • [Presentation] Aging of human ES cell-derived vascular cells: analysis of early and late passage cells.2010

    • Author(s)
      Yamahara K, Nishi T, Homma K, Takesue S, Yamaguchi S, Sone M, Itoh H.
    • Organizer
      XX World Congress of the International Society for Heart Research (ISHR)
    • Year and Date
      20100500
  • [Presentation] iPS細胞由来血管前駆細胞を用いた新規下肢動脈閉塞性疾患治療法の開発2009

    • Author(s)
      山原研一
    • Organizer
      第50回日本脈管学会 共催シンポジウム
    • Year and Date
      20091000
  • [Book] 血管の再生2008

    • Author(s)
      山原研一、曽根正勝、伊藤裕
    • Total Pages
      52-64
    • Publisher
      真興出版
  • [Remarks] ホームページ等

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi