2010 Fiscal Year Final Research Report
Aging and oxidative stress in inflammatory lung disease
| Project/Area Number |
21790758
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
NAGAI Katsura Hokkaido University, 大学院・医学研究科, 助教 (40374293)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / 加齢 / 喫煙 |
|---|
| Research Abstract |
1) Protein S-glutathionylation in the epithelial lining fluid during allergic airway inflammation. The S-glutathionylated protein in bronchoalveolar fluid (BALF) was temporally present only at 8 h in ovalbumin(OVA) stimulated eosinophilic inflammation model. The level of glutaredoxin1 (GRx1) was significantly higher at 24 and 48 h. 2) Aging affects the airway expression of NF-E2-Related Factor 2 (Nrf2) and γ-glutamyl cysteine synthetase regulatory subunit (GCLm) in response to cigarette smoke. Airway epithelial cells from the subsegmental bronchus were harvested by brushing through a flexible bronchoscope (n=30). The levels of Nrf2 mRNA and GCLm mRNA were significantly decreased in current smokers compared to never-smokers in the old subjects, but not in the young subjects. The ratio of nuclear Nrf2-positive cells tended to be increased (p=0.008) in current smokers compared to never-smokers in the young subjects, but not in old subjects.
|
Research Products
(13 results)
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Duration of cigarette smoke (CS) exposure affects the resolution of lung inflammation after cessation in mice.2009
Author(s)
Odajima N, Betsuyaku T, Inomata T, Yoshida T, Moriyama C, Suzuki K, Nagai K, Nasuhara Y, Nishimura M.
Organizer
2009 May 17^<th> The San Diego Convention Center
Place of Presentation
San Diego, CA,United States.
Year and Date
2009-05-17
-
