2011 Fiscal Year Final Research Report

The effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AMPK)on malignant mesothelioma cell growth and survival interval in an implant animal model of malignant mesothelioma

Research Project

Project/Area Number	21790763
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Respiratory organ internal medicine
Research Institution	Tohoku University
Principal Investigator	NIU Kaijun 東北大学, 大学院・医工学研究科, 准教授 (70447134)
Project Period (FY)	2009 – 2011
Keywords	非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / ヒト悪性中皮腫
Research Abstract	In vitro, AICAR treatment significantly impaired the cell proliferation rate of malignant mesothelioma (MM)cell lines. In vivo, treatment with AICAR significantly decreased the growth rate of MM, which was accompanied by an increase in p53/phosphor-p53 levels, and down-regulated protein levels of phosphor-Akt and p70/phosphor-p70. Similar intracellular pathways are also observed in vitro experiment. These effects partly involved induction of growth arrest and apoptosis to MM cells. AICAR treatment activated AMPK. Finally, AICAR treatment also significantly extended survival interval in an implant animal model of MM. These findings suggested that AICAR or the induction of AMPK activity is an important tactic for developing therapeutic strategies against MM.

(2 results)