2010 Fiscal Year Final Research Report

Antimicrobial peptides, defensin, in inflammatory diseases

Research Project

Project/Area Number	21790766
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Respiratory organ internal medicine
Research Institution	The University of Tokyo
Principal Investigator	YAMAGUCHI Yasuhiro The University of Tokyo, 医学部附属病院, 講師 (60376473)
Project Period (FY)	2009 – 2010
Keywords	免疫学 / 応用動物 / 微生物 / 低体重
Research Abstract	Human・-defensin-3 and its mouse homologue, mouse・-defensin-14, showed potent cytotoxicity to mammalian cancer cells compared to other defensin isoforms. After implanting LLC adenocarcinoma in C57BL6 mice, we continuously injected mBD-14 peptide into the subcutaneous tissues around the tumor. The growth of tumor was significantly inhibited by mBD-14 peptide. In addition, the growth of LLC adenocarcinoma was significantly promoted in mBD-14-deficient mice 7 days after the implantation.

(4 results)