The effect of maternal immunity on the onset of infant asthma.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790769
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Kobe University
• Principal Investigator: KOBAYASHI Kazuyuki Kobe University, 大学院・医学研究科, 助教 (50403275)
• Project Period (FY): 2009 – 2010
• Keywords: 母子垂直伝搬 / 免疫グロブリン / FcRn

Research Abstract

By sensitizing mother before pregnancy and inducing allergic airway inflammation during pregnancy, serum OVA-specific IgE level and sensitivity for asthma was significantly reduced in wild-type offspring. It was assumed that maternal passive immunity by the transportation of antigen specific IgG may regulate allergic airway inflammation. The administration of antigen specific IgG into mother mice during lactating period reduced airway inflammation of offspring in wild type mice, but not in FcRn deficient mice. It is concluded that he transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in the FcRn-dependent manner.

Research Products

• [Journal Article] The inhibitory effects of intravenous administration of rabbit immunoglobulin G on airway inflammation are dependent upon Fcy receptor IIb on CD11c(+) dendritic cells in a murine model. (2010)
  • Author(s): Yamamoto M, Kobayashi K, Ishikawa Y, Nakata K, Funada Y, Kotani Y, Masuda A, Takai T, Azuma T, Yoshida M, Nishimura Y.
  • Journal Title: Clin Exp Immunol. 162(2) Pages: 315-24
  • Peer Reviewed
• [Journal Article] The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner. (2010)
  • Author(s): Nakata K, Kobayashi K, Ishikawa Y, Yamamoto M, Funada Y, Kotani Y, Blumberg RS, Karasuyama H, Yoshida M, Nishimura Y.
  • Journal Title: Biochem Biophys Res Commun. 395(2) Pages: 238-43
  • Peer Reviewed
• [Journal Article] アレルギー性気道炎症におけるIgGとFc受容体を介したはたらき (2010)
  • Author(s): 山本正嗣, 小林和幸, 西村善博
  • Journal Title: 臨床免疫・アレルギー科 54巻5号 Pages: 583-587
• [Presentation] アレルギー性気道炎症におけるFcRnの役割 (2010)
  • Author(s): 中田恭介, 小林和幸, 石川結美子, 他
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2010-04-24
• [Presentation] The role of FcRn in the allergic airway inflammation (2009)
  • Author(s): K.Nakata, K.Kobayashi, et. al.
  • Organizer: ERS2009
  • Place of Presentation: ウイーン
  • Year and Date: 20090912-20090916
• [Remarks] ホームページ等