2010 Fiscal Year Final Research Report
Analysis of Severe Influenza Pneumonia -Control of Host and Pathogen Factors in Influenza and Bacteria Co-infected Mice Models
| Project/Area Number |
21790774
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
SEKI Masafumi Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (80432970)
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| Co-Investigator(Kenkyū-buntansha) |
KOHNO Shigeru 長崎大学, 大学院・医歯薬学総合研究科, 助教 (80136647)
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| Project Period (FY) |
2009 – 2010
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| Keywords | インフルエンザ / 細菌感染 / 肺炎 |
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| Research Abstract |
We examined the mechanisms of severe influenza virus-related pneumonia. In pathogens factor, quorum sensing related genes were deleted in Pseudomonas, and we infected them to mice. Toxin were decreased, but no significant differences were found in vivo. However, apoptosis were detected in virus and Streptococcus co-infected mice, and excessive inflammation and pulmonary edema according to cytokine storm were observed in TLR-related genes-deleted mice by influenza virus infection alone. Excessive inflammation might be related to progression of severe pneumonia
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Research Products
(30 results)
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[Journal Article] A case of intravascular large B-cell lymphoma(IVLBCL)with no abnormal findings on chest computed tomography diagnosed by random transbronchial lung biopsy.2010
Author(s)
Kaku N, Seki M, Doi S, Hayashi T, Imanishi D, Imamura Y, Kurihara S, Miyazaki T, Izumikawa K, Kakeya H, Yamamoto Y, Yanagihara K, Tashiro T, Kohno S.
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Journal Title
Intern Med. 49
Pages: 2697-2701
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[Journal Article] Legionella pneumophila Induces Cathepsin B-dependent Necrotic Cell Death with Releasing High Mobility Group Box1 in Macrophages.2010
Author(s)
Morinaga Y, Yanagihara K, Nakamura S, Hasegawa H, Seki M, Izumikawa K, Kakeya H, Yamamoto Y, Yamada Y, Kohno S, Kamihira S.
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Journal Title
Respir Res. 22;11
Pages: 158.
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[Journal Article] Importance of Controlling Drug-resistant Pseudomonas aeruginosa Infection: Experience from Lung Transplantation in a Cystic Fibrosis Case.2010
Author(s)
Yamamoto Y, Izumikawa K, Hara A, Fujita H, Amenomori M, Sakamoto N, Seki M, Kakeya H, Yanagihara K, Takasaki K, Miyazaki T, Tsuchiya T, Yamasaki N, Tagawa T, Nagayasu T, Kohno S.
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Journal Title
Intern Med. 49
Pages: 2353-2358
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[Journal Article] In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.2010
Author(s)
Morinaga Y, Yanagihara K, Araki N, Yamada K, Seki M, Izumikawa K, Kakeya H, Yamamoto Y, Yamada Y, Kohno S, Kamihira S.
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Journal Title
Exp Lung Res. 36
Pages: 484-490
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[Journal Article] Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit.2010
Author(s)
Yanagihara K, Kitagawa Y, Tomonaga M, Tsukasaki K, Kohno S, Seki M, Sugimoto H, Shimazu T, Tasaki O, Matsushima A, Ikeda Y, Okamoto S, Aikawa N, Hori S, Obara H, Ishizaka A, Hasegawa N, Takeda J, Kamihira S, Sugahara K, Asari S, Murata M, Kobayashi Y, Ginba H, Sumiyama Y, Kitajima M.
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Journal Title
Crit Care. 14
Pages: R159
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[Journal Article] Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata.2010
Author(s)
Miyazaki T, Yamauchi S, Inamine T, Nagayoshi Y, Saijo T, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Miyazaki Y, Kohno S.
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Journal Title
Antimicrob Agents Chemother. 54
Pages: 1639-1643
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[Journal Article] Diffuse Alveolar Hemorrhage following Itraconazole Injection.2010
Author(s)
Izumikawa K, Nakano K, Kurihara S, Imamura Y, Yamamoto K, Miyazaki T, Sakamoto N, Seki M, Ishimatsu Y, Kakeya H, Yamamoto Y, Yanagihara K, Tsuchiya T, Yamasaki N, Tagawa T, Mukae H, Nagayasu T, Kohno S.
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Journal Title
Intern Med. 49
Pages: 497-500
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[Journal Article] Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata.2010
Author(s)
Miyazaki T, Inamine T, Yamauchi S, Nagayoshi Y, Saijo T, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Miyazaki Y, Kohno S.
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Journal Title
FEMS Yeast Res. 10
Pages: 343-352
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[Journal Article] Skn7p Is Involved in Oxidative Stress Response and Virulence of Candida glabrata.2010
Author(s)
Saijo T, Miyazaki T, Izumikawa K, Mihara T, Takazono T, Kosai K, Imamura Y, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Kohno S.
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Journal Title
Mycopathologia. 169
Pages: 81-90
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[Journal Article] Efficacy of clarithromycin against experimentally induced pneumonia caused by clarithromycin-resistant Haemophilus influenzae in mice.2010
Author(s)
Nakamura S, Yanagihara K, Araki N, Yamada K, Morinaga Y, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Kamihira S, Kohno S.
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Journal Title
Antimicrob Agents Chemother. 54
Pages: 757-762
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