2010 Fiscal Year Final Research Report
Regulations of inflammatory responses through Toll-like receptors and inflammasomes by pulmonary collectins.
| Project/Area Number |
21790776
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
ONO Chiaki (西谷 千明) Sapporo Medical University, 医学部, 助教 (30381255)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 肺サーファクタント / トル様受容体(TLR) / 酸化肺サーファクタント脂質 / リポ多糖(LPS) / 炎症応答 |
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| Research Abstract |
In this study, we demonstrated that oxidized surfactant lipids (oxSLs) and oxidized PAPC (1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine) inhibit LPS-induced inflammatory responses by different mechanisms. Because the generation of reactive oxygen species is one of the characteristics of inflammation that results in the oxidation of host lipids, oxSLs may contribute to reduce the excessive inflammatory response to LPS.
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[Journal Article] Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth.2010
Author(s)
Sawada K., Ariki S., Kojima T., Saito A., Yamazoe M., Nishitani C., Shimizu T., Takahashi M., Mitsuzawa H., Yokota S., Sawada N., Fujii N., Takahashi H., Kuroki Y.
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Journal Title
J Biol Chem. 285
Pages: 8434-8443
Peer Reviewed
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