2010 Fiscal Year Final Research Report
Development of inhaled biodegradable nano/micro-particles incorporated immuno-modulatory DNA for treatment of inflammatory lung diseases
| Project/Area Number |
21790778
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
SATO Takashi Yokohama City University, 医学部, 助教 (70510436)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 免疫調節性DNA / ナノ粒子 |
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| Research Abstract |
Recently we have developed biomaterials incorporated oligodeoxynucleotide (ODN) achieving acceleration of epithelial cell repair. In this regard, we focused on the effective delivery of ODN to pulmonary immune cells such as alveolar macrophages and bronchial associated lymphoid tissue. Finally, we synthesized biodegradable polyketal nano-particles containing ODN, which showed sustaining-hydrolyzed and preferably degraded in acidic condition. Thereby, we could extend our studies in the local administrative inhaled approach in lung inflammation study.
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