Adipocytokine as an exacerbation factor for asthma and its possible involvement in therapeutic target for asthma

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790779
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Osaka City University
• Principal Investigator: ASAI Kazuhisa Osaka City University, 大学院・医学研究科, 研究員 (10382053)
• Project Period (FY): 2009 – 2010
• Keywords: 閉塞性肺疾患

Research Abstract

We recruited 25 obesity asthma(BMI≧25,n=5) and non-obesityasthma(BMI<25,n=16). We examined asthma severity in dices such as %FEV1, PC20, FeNO and adiponectin and leptin concentrations in plasma and induced sputum supernatant in all asthmatic patients. Although there were significant correlations between adipocytokine concentrations and BMI in asthmatic patients, there were not significant correlations between adipocytokine concentrations and asthma severity indices.

Research Products

• [Journal Article] Potential roles of pentosidine in age-related and disease-related impairment of pulmonary functions in patients with asthma. (2011)
  • Author(s): Kanazawa H, Tochino Y, Kyoh S, Ichimaru Y, Asai K, Hirata K.
  • Journal Title: J Allergy Clin Immunol. (in press).
  • Peer Reviewed
• [Journal Article] Increased levels of HMGB-1 and endogenous secretory RAGE in induced sputum from asthmatic patients. (2011)
  • Author(s): Watanabe T, Asai K, Fujimoto H, Tanaka H, Kanazawa H, Hirata K.
  • Journal Title: Respir Med. 105(4) Pages: 519-25
  • Peer Reviewed
• [Journal Article] 喘息とCOPDをめぐって類似点と相違点 (2010)
  • Author(s): 平田一人, 浅井一久
  • Journal Title: 治療ステロイドの効果の差アレルギー・免疫 17巻12号 Pages: 2034-2042
• [Journal Article] 咳の新しい捉え方 (2010)
  • Author(s): 平田一人, 浅井一久
  • Journal Title: COPD成人病と生活習慣病 40巻11号 Pages: 1285-1290
• [Journal Article] Validity of measurement of two specific biomarkers for the assessment of small airways inflammation in asthma. (2010)
  • Author(s): Kanazawa H, Kyoh S, Asai K, Hirata K.
  • Journal Title: J Asthma. 47(4) Pages: 400-406
  • Peer Reviewed
• [Journal Article] Increased levels of N(epsilon)-(carboxymethyl)lysine in epithelial lining fluid from peripheral airways in patients with chronic obstructive pulmonary disease : a pilot study. (2010)
  • Author(s): Kanazawa H, Kodama T, Asai K, Matsumura S, Hirata K.
  • Journal Title: Clin Sci (Lond). 119(3) Pages: 143-149
  • Peer Reviewed
• [Journal Article] 喫煙とCOPD (2010)
  • Author(s): 平田一人, 浅井一久
  • Journal Title: 喫煙が気管支拡張薬に及ぼす影響呼吸器内科 17巻5号 Pages: 450-455
• [Journal Article] 呼吸不全の実地診療治療ストラテジーの新たな展開 (2010)
  • Author(s): 平田一人, 浅井一久
  • Journal Title: 呼吸不全の実地診療・セミナー/呼吸不全をきたす疾患の実地診療のポイント気管支喘息急性期から慢性期のアプローチの実際Medical Practice 27巻4 Pages: 633-639
• [Journal Article] 増加するアレルギー疾患内科医にとっての最良のアプローチとは (2010)
  • Author(s): 平田一人, 浅井一久
  • Journal Title: 成人喘息への理解と対応合併病態への対応COPDと喘息の合併内科 105巻4号 Pages: 644-649
• [Journal Article] 吸入療法の新展開吸入去痰薬の新しい動向 (2010)
  • Author(s): 浅井一久, 平田一人
  • Journal Title: 吸入療法 2巻1号 Pages: 74-81
• [Journal Article] 呼吸不全の実地診療治療ストラテジーの新たな展開 (2010)
  • Author(s): 平田一人, 浅井一久
  • Journal Title: 呼吸不全の実地診療・セミナー/呼吸不全をきたす疾患の実地診療のポイント気管支喘息急性期から慢性期のアプローチの実際Medical Practice 27巻4号 Pages: 633-639
• [Journal Article] 末梢気道をめぐって (2009)
  • Author(s): 平田一人, 浅井一久
  • Journal Title: 末梢気道障害が関与する呼吸器疾患(喘息を除く)アレルギー・免疫 17巻1号 Pages: 30-35
• [Journal Article] 最新のCOPD治療大規模臨床試験の結果から (2009)
  • Author(s): 平田一人, 浅井一久
  • Journal Title: COPDにおける早期治療介入の有用性を示したチオトロピウムの長期大規模臨床試験UPLIFT Study医学のあゆみ 231巻4号 Pages: 271-276
• [Journal Article] 咳嗽そのcommonで多様な疾患領域 (2009)
  • Author(s): 平田一人, 浅井一久
  • Journal Title: 咳嗽の治療綜合臨床 58巻10号 Pages: 2067-2071
• [Journal Article] Increased levels of angiopoietin-2 in induced sputum from smoking asthmatic patients. (2009)
  • Author(s): Kanazawa H, Asai K, Tochino Y, Kyoh S, Kodama T, Hirata K.
  • Journal Title: Clin Exp Allergy. 39(9) Pages: 1330-1337
  • Peer Reviewed
• [Journal Article] Potential mechanisms of airway remodeling initiated by activated thrombin in asthma. (2009)
  • Author(s): Kanazawa H, Kyoh S, Tochino Y, Kodama T, Asai K, Hirata K.
  • Journal Title: Arerugi.(Japanese.) 58(5) Pages: 554-559
• [Presentation] 気管支喘息におけるHigh mobility group box1 (HMGB-1)の関与についての検討 (2010)
  • Author(s): 渡辺徹也, 浅井一久, 小林大起, 白土直子, 藤本寛樹, 鴨井博, 金澤博, 平田一人
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] Advanced glycation end products stimulate vascular endothelial growth factor production from human airway epithelial cells in vitro and in vivo. (2010)
  • Author(s): Asai K, Kanazawa H, Watanabe T, Fujimoto H, Kyoh S, Hirata K.
  • Organizer: American Thoracic Society
  • Place of Presentation: ニューオリンズ
  • Year and Date: 2010-05-16
• [Presentation] 終末糖化産物は気道上皮におけるVascular Endothelial Growth Factorの産生を増強する (2010)
  • Author(s): 浅井一久, 金澤博, 小林大起, 白土直子, 渡辺徹也, 藤本寛樹, 児玉豊城, 松村佐恵子, 姜成勲, 鴨井博, 平田一人
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-24
• [Book] 最新医学別冊「新しい診断と治療のABC」呼吸器2喘息(改訂第2版)(第4章管理・治療薬物療法・選択基準) (2011)
  • Author(s): 浅井一久, 平田一人
  • Publisher: (共著、印刷中)