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2011 Fiscal Year Final Research Report

Mechanisms and management of COPD exacerbations : role of toll-like receptors on the activation of neutrophil

Research Project

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Project/Area Number 21790782
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionWakayama Medical University

Principal Investigator

KOARAI Akira  和歌山県立医科大学, 医学部, 助教 (80458059)

Project Period (FY) 2009 – 2011
Keywords慢性閉塞性肺疾患 / 急性増悪 / 酸化ストレス / ウイルス / toll様受容体
Research Abstract

In the present study, we demonstrated that one of toll like receptors, TLR8-mediated neutrophilic responses were markedly potentiated via NF-κB signaling by oxidative stress which is important in the pathophysiology of COPD. This might potentiate the neutrophilic inflammation during the viral-induced COPD exacerbations.

  • Research Products

    (32 results)

All 2012 2011 2010 2009

All Journal Article (16 results) (of which Peer Reviewed: 12 results) Presentation (14 results) Book (2 results)

  • [Journal Article] Expression of muscarinic receptors by human macrophages2012

    • Author(s)
      Koarai A, et al.
    • Journal Title

      Eur Respir J

      Volume: 39 Pages: 698-704

    • DOI

      DOI:10.1183/09031936.00136710

    • Peer Reviewed
  • [Journal Article] Validation of a compact motion sensor for the measurement of physical activity in patients with chronic obstructive pulmonary disease2012

    • Author(s)
      Sugino A, Koarai A, et al.
    • Journal Title

      Respiration

      Volume: 83 Pages: 300-307

    • DOI

      DOI:10.1159/000330046

    • Peer Reviewed
  • [Journal Article] Increase of nitrosative stress in patients with eosinophilic pneumonia2011

    • Author(s)
      Furukawa K, Koarai A, et al.
    • Journal Title

      Respir Res

      Volume: 12 Pages: 81-91

    • DOI

      DOI:10.1186/1465-9921-12-81

    • Peer Reviewed
  • [Journal Article] Exhaled nitric oxide cutoff values for asthma diagnosis according to rhinitis and smoking status in Japanese subjects2011

    • Author(s)
      Matsunaga K, Koarai A, et al.
    • Journal Title

      Allergol Int

      Volume: 60 Pages: 331-337

    • DOI

      DOI:10.2332/allergolint.10-OA-0277

    • Peer Reviewed
  • [Journal Article] Improvement of Airflow Limitation by Fluticasone Propionate/Salmeterol in Chronic Obstructive Pulmonary Disease : What is the Specific Marker?2011

    • Author(s)
      Akamatsu K, Koarai A, et al.
    • Journal Title

      Front Pharmacol

      Volume: 2 Pages: 36-41

    • DOI

      DOI:10.3389/fphar.2011.00036

    • Peer Reviewed
  • [Journal Article] 拡散2011

    • Author(s)
      小荒井晃
    • Journal Title

      呼吸

      Volume: 30 Pages: 358-364

  • [Journal Article] COPDと自然免疫2011

    • Author(s)
      小荒井晃
    • Journal Title

      総合臨床

      Volume: 60 Pages: 508-514

  • [Journal Article] COPDの新しい臨床研究-UPLIFT-TORCH以後2011

    • Author(s)
      小荒井晃
    • Journal Title

      呼吸と循環

      Volume: 59 Pages: 1009-1015

  • [Journal Article] Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells2010

    • Author(s)
      Koarai A, et al.
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 42 Pages: 651-660

    • DOI

      DOI:10.1165/rcmb.2008-0345OC

    • Peer Reviewed
  • [Journal Article] High COPD prevalence in patients with liver disease2010

    • Author(s)
      Minakata Y, Koarai A, et al.
    • Journal Title

      Intern Med

      Volume: 49 Pages: 2687-91

    • URL

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & dopt=Citation & list_uids=21173543

    • Peer Reviewed
  • [Journal Article] Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects2009

    • Author(s)
      Yanagisawa S, Koarai A, et al.
    • Journal Title

      Respir Res

      Volume: 10 Pages: 50-62

    • DOI

      DOI:10.1186/1465-9921-10-50

    • Peer Reviewed
  • [Journal Article] Activation of toll-like receptor 3 augments myofibroblasts differentiation2009

    • Author(s)
      Sugiura H, Koarai A, et al.
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 40 Pages: 654-662

    • DOI

      DOI:10.1165/rcmb.2008-0371OC

    • Peer Reviewed
  • [Journal Article] The possible role of hematopoietic cell kinase in the pathophysiology of chronic obstructive pulmonary disease2009

    • Author(s)
      Yanagisawa S, Koarai A, et al.
    • Journal Title

      Chest

      Volume: 135 Pages: 94-101

    • DOI

      DOI:10.1378/chest.07-3020

    • Peer Reviewed
  • [Journal Article] Clinical Application of Exhaled Breath Condensate Analysis in Asthma : Prediction of FEV(1) Improvement by Steroid Therapy2009

    • Author(s)
      Matsunaga K, Koarai A, et al.
    • Journal Title

      Respiration

      Volume: 78 Pages: 393-398

    • DOI

      DOI:10.1159/000243551

    • Peer Reviewed
  • [Journal Article] Molecular mechanism of the additive effects of leukotriene modifier in asthmatic patients receiving steroid therapy2009

    • Author(s)
      Matsunaga K, Koarai A, et al.
    • Journal Title

      Allergol Int

      Volume: 58 Pages: 89-96

    • DOI

      DOI:10.2332/allergolint.08-OA-0014

    • Peer Reviewed
  • [Journal Article] 喘息とCOPDの増悪をめぐって増悪から回復期の喘息治療2009

    • Author(s)
      小荒井晃、杉浦久敏
    • Journal Title

      呼吸と循環

      Volume: 57 Pages: 169-174

  • [Presentation] 非結核性抗酸菌症に合併したANCA関連血管炎の一例2011

    • Author(s)
      神田佳典、小荒井晃
    • Organizer
      第78回日本呼吸器学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2011-12-03
  • [Presentation] 25-Hydroxycholesterolの気道上皮におけるサイトカイン産生およびTLR3受容体応答に与える影響の検討2011

    • Author(s)
      小荒井晃
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-10
  • [Presentation] Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells2011

    • Author(s)
      A Koarai, et al
    • Organizer
      AAAS and AP Airway Disease Summit
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2011-10-15
  • [Presentation] Cigarette smoking augments toll-like receptor 3 expression and responses in macrophages2011

    • Author(s)
      A Koarai, et al
    • Organizer
      ERS Annual Congress
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      2011-09-25
  • [Presentation] 25-hydroxycholesterol enhances cytokines release and toll-like receptor 3 responses in human airway epithelial cells2011

    • Author(s)
      A Koarai, et al
    • Organizer
      ATS International Conference
    • Place of Presentation
      Denver, USA
    • Year and Date
      2011-05-17
  • [Presentation] COPD急性増悪機序の解明および薬物療法の可能性2010

    • Author(s)
      小荒井晃
    • Organizer
      第19回Pneumo forum
    • Place of Presentation
      東京
    • Year and Date
      2010-11-13
  • [Presentation] Expression of toll-like receptor 3 in alveolar macrophages from patients with COPD2010

    • Author(s)
      Koarai A, et al
    • Organizer
      ERS Annual Congress
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-09-21
  • [Presentation] Oxidative stress enhances TLR3 response to double-stranded RNA in airway epithelial cells2010

    • Author(s)
      Koarai A, et al
    • Organizer
      COPD symposium in ASIA2010
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2010-07-31
  • [Presentation] 酸化ストレスのdsRNAウイルス刺激応答に与える影響の検討2010

    • Author(s)
      小荒井晃
    • Organizer
      第81回閉塞性肺疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-24
  • [Presentation] Oxidative stress enhances TLR3 response to double-stranded RNA in airway epithelial cells2010

    • Author(s)
      Koarai A, et al
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-06-16
  • [Presentation] 酸化ストレスのヒト気道上皮におけるdsRNAウイルス刺激応答に対する影響の検討2010

    • Author(s)
      小荒井晃
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-25
  • [Presentation] 化学療法が奏効した肺大細胞癌(LCNEC)の1例2009

    • Author(s)
      中谷佳裕、小荒井晃
    • Organizer
      第37回和歌山悪性腫瘍研究会
    • Place of Presentation
      和歌山
    • Year and Date
      2009-12-05
  • [Presentation] 酸化ストレスの気道上皮におけるdsRNAウイルス刺激応答に対する影響の検討2009

    • Author(s)
      小荒井晃
    • Organizer
      第49回日本呼吸器学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-13
  • [Presentation] Oxidative stress enhances TLR3 response to double-stranded RNA in airway epithelial cells2009

    • Author(s)
      Koarai A, et al
    • Organizer
      ATS International Conference
    • Place of Presentation
      San Diego, California
    • Year and Date
      2009-05-18
  • [Book] 薬物療法(慢性閉塞性肺疾患(COPD)のマネジメント改訂版)2010

    • Author(s)
      小荒井晃、一ノ瀬正和
    • Total Pages
      87-103
    • Publisher
      医薬ジャーナル社
  • [Book] 肺胞蛋白症(今日の治療指針2010)2010

    • Author(s)
      小荒井晃
    • Total Pages
      261-262
    • Publisher
      医学書院

URL: 

Published: 2013-07-31  

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