2010 Fiscal Year Final Research Report
The role of autophagic regulation of cellular senescence in COPD pathogenesis
| Project/Area Number |
21790789
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
ARAYA Jun Jikei University School of Medicine, 医学部, 講師 (90468679)
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| Co-Investigator(Renkei-kenkyūsha) |
MORIKAWA Toshiaki 東京慈恵会医科大学, 医学部, 教授 (60292025)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 慢性閉塞性肺疾患 / オートファジー / TGF-β |
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| Research Abstract |
We demonstrated that autophagy is involved in the suppression of cigarette smoke extract(CSE)-induced cellular senescence in human bronchial epithelial cells. Furthermore, p62-mediated selective autophagic degradation of ubiquitinated proteins is implicated in the regulation of cellular senescence in association with COPD pathogenesis.
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[Journal Article] Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells.2011
Author(s)
Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K.
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Journal Title
Am J Physiol Lung Cell Mol Physiol. 300(3)
Pages: L391-401
Peer Reviewed
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