2010 Fiscal Year Final Research Report
L-type fatty acid-binding protein in septic acute kidney injury
| Project/Area Number |
21790795
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
DOI Kent 東京大学, 医学部附属病院, 助教 (80505892)
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| Co-Investigator(Renkei-kenkyūsha) |
NOIRI Eisei 東京大学, 医学部附属病院, 准教授 (00301820)
YAHAGI Naoki 東京大学, 医学部附属病院, 教授 (60158045)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 腎臓学 / 敗血症性急性腎不全 |
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| Research Abstract |
Multiple organ failure, especially acute renal failure, complicated with sepsis shows high mortality rate. This study evaluated the utility of urinary L-type fatty acid-binding protein (L-FABP) for early diagnosis of septic acute renal failure using mouse sepsis models. Results of this study demonstrated urinary L-FABP could detect septic acute renal failure earlier than serum creatinine and urinary NAG with higher accuracy.
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[Journal Article] Urinary L-type fatty acid-binding protein as a new biomarker of sepsis complicated with acute kidney injury2010
Author(s)
Doi K, Noiri E, Maeda-Mamiya R, Ishii T, Negishi K, Hamasaki Y, Fujita T, Yahagi N, Koide H, Sugaya T, Nakamura T.
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Journal Title
Crit Care Med.
Volume: 38
Pages: 2037-42
Peer Reviewed
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[Journal Article] Mild elevation of urinary biomarkers in pre-renal acute kidney injury
Author(s)
Doi K, Katagiri D, Negishi K, Hasegawa S, Hamasaki Y, Fujita T, Matsubara T, Ishii T, Yahagi N, Sugaya T, Noiri E
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Journal Title
Kidney Int
Volume: (in press)
Peer Reviewed
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