2011 Fiscal Year Final Research Report
Sympathoexcitation by brain oxidative stress in hypertension associated with metabolic syndrome and chronic kidney disease
| Project/Area Number |
21790797
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUJITA Megumi 東京大学, 医学部附属病院, 特任助教 (50447405)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 高血圧学 |
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| Research Abstract |
We have demonstrated that sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in chronic kidney disease(CKD) model, high salt-loaded uninephrectomized Sprague-Dawley rats. In CKD rats, responses of renal sympathetic nerve to acute intracerebroventricular(ICV) tempol and hypothalamic oxidative stress level were significantly increased. Moreover, chronic ICV tempol showed sympathoinhibitory and depressor effect, along with improvement of renal function.
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