2011 Fiscal Year Final Research Report
Mechanism of IgA deposition in mesangial cells in IgA nephropathy and application for therapy
| Project/Area Number |
21790800
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腎臓学 |
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| Research Abstract |
Immunoglobulin A nephropathy(IgAN) is the most common form of primary glomerulonephritis and is characterized by glomerular mesangial IgA1 deposition, however, precise mechanism of IgA1 deposition are still unclear. The aim of the present study is to identify the receptor for IgA1 in mesangial cells using IgA1 probe, and integrinα1/β1 andα2/β1 heterodimer was identified as the receptors for IgA1.
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