2010 Fiscal Year Final Research Report
Gene polymorphisms contributing to progression of chronic glomerulonephritis
| Project/Area Number |
21790809
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAMOTO Ryohei Osaka University, 医学部附属病院, 医員 (00533853)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 慢性糸球体腎炎 / IgA腎症 / 遺伝子多型 / single nucleotide polymorphism (SNP) |
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| Research Abstract |
The aim of the present multicenter longitudinal cohort was identification of gene polymorphisms contributing to progression of chronic glomerulonephritis among 100 kinds of atherosclerotic diseases-related gene polymorphisms, mainly single Nucleotide Polymorphisms (SNPs). We determined 100 gene polymorphisms of 320 patients with IgA nephropathy, a most common chronic glomerulonephritis, and identified glycoprotein Ia (GPIa) C807T/G873A and intracellular adhesion molecule-1 (ICAM-1) A1548G(K469E) as significant predictors of progression of IgA nephropathy. Based on the clinical database of approximately 1000 patients with IgA nephropathy, we also revealed the number of cigarettes was a significant predictor of progression of IgA nephropathy. The results of the present study strongly suggested that atherosclerotic disease-related factors play pivotal roles in progression of IgA nephropathy, providing a deep insight into the treatment strategy of IgA nephropathy.
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[Journal Article] Cigarette smoking and progression of IgA nephropathy.2010
Author(s)
Yamamoto R, Nagasawa Y, Shoji T, Iwatani H, Hamano T, Kawada N, Inoue K, Uehata T, Kaneko T, Okada N, Moriyama T, Horio M, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y
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Journal Title
Am J Kidney Dis 56
Pages: 313-324
Peer Reviewed
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[Journal Article] Urinary type iv collagen in nondiabetic kidney disease.2010
Author(s)
Furumatsu Y, Nagasawa Y, Shoji T, Yamamoto R, Iio K, Matsui I, Takabatake Y, Kaimori JY, Iwatani H, Kaneko T, Tsubakihara Y, Imai E, Isaka Y, Rakugi H
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Journal Title
Nephron Clin Pract 117
Pages: c160-c166
Peer Reviewed
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[Journal Article] Impact of age and overt proteinuria on outcomes of stage 3 to 5 chronic kidney disease in a referred cohort.2010
Author(s)
Obi Y, Kimura T, Nagasawa Y, Yamamoto R, Yasuda K, Sasaki K, Kitamura H, Imai E, Rakugi H, Isaka Y, Hayashi T
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Journal Title
Clin J Am Soc Nephrol 5
Pages: 1558-1565
Peer Reviewed
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[Journal Article] Microarray analysis of tonsils in immunoglobulin a nephropathy patients.2010
Author(s)
Iio K, Nagasawa Y, Iwatani H, Yamamoto R, Horii A, Okuzaki D, Furumatsu Y, Inohara H, Nojima H, Imai E, Isaka Y, Rakugi H
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Journal Title
Biochem Biophys Res Commun 393
Pages: 565-570
Peer Reviewed
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[Journal Article] Specialist care and improved long-term survival of dialysis patients.2010
Author(s)
Furumatsu Y, Nagasawa Y, Yamamoto R, Iio K, Iwatani H, Matsui I, Takabatake Y, Kawada N, Shoji T, Imai E, Isaka Y, Rakugi H
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Journal Title
Nephrol Dial Transplant 25
Pages: 1930-1935
Peer Reviewed
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[Journal Article] A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of polymorphism research to distinguish genetic factors contributing to progression of iga nephropathy (PREDICT-IgAN).2009
Author(s)
Yamamoto R, Nagasawa Y, Shoji T, Inoue K, Uehata T, Kaneko T, Okada T, Yamauchi A, Tsubakihara Y, Imai E, Isaka Y, Rakugi H
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Journal Title
Nephrol Dial Transplant 24
Pages: 3686-3694
Peer Reviewed
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