2010 Fiscal Year Final Research Report
Functional analysis of ERK signaling pathway in ERK1/2 kidney specific knockout mice
| Project/Area Number |
21790818
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SUGIYAMA Noriyuki Kyoto Prefectural University of Medicine, 医学研究科, 助教 (90381954)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 腎臓学 / 嚢胞腎 |
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| Research Abstract |
This study is that analysis of Erk in kidney. We obtained that Erk functioned renal regeneration after ischemia-refusion.
The next study indicates that random oriented cell division is an initial event for renal tubule expansion and precedes cell proliferation in inv mutant kidneys. However, our results do not support the hypothesis that the canonical Wnt signaling pathway is involved in renal cyst development of inv mutant mice.
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[Journal Article] Abnormal Epithelial Cell Polarity and Ectopic Epidermal Growth Factor Receptor (EGFR) Expression Induced in Emx2 KO Embryonic Gonads.2010
Author(s)
Kusaka M, Katoh-Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, Sugiyama N, Sugimoto Y, Okuno Y, Kodama R, Iizuka-Kogo A, Senda T, Sasaoka T, Kitamura K, Aizawa S, Morohashi KI.
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Journal Title
Endocrinology. 151(12)
Pages: 5893-5904
Peer Reviewed
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