• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

Functional analysis of ERK signaling pathway in ERK1/2 kidney specific knockout mice

Research Project

  • PDF
Project/Area Number 21790818
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

SUGIYAMA Noriyuki  Kyoto Prefectural University of Medicine, 医学研究科, 助教 (90381954)

Project Period (FY) 2009 – 2010
Keywords腎臓学 / 嚢胞腎
Research Abstract

This study is that analysis of Erk in kidney. We obtained that Erk functioned renal regeneration after ischemia-refusion.
The next study indicates that random oriented cell division is an initial event for renal tubule expansion and precedes cell proliferation in inv mutant kidneys. However, our results do not support the hypothesis that the canonical Wnt signaling pathway is involved in renal cyst development of inv mutant mice.

  • Research Products

    (13 results)

All 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] The canonical Wnt signaling pathway is not involved in renal cyst development in the kidneys of inv mutant mice.2011

    • Author(s)
      Sugiyama N, Tsukiyama, T Yamaguchi TP, Yokoyama T.
    • Journal Title

      Kidney Int. 79(9)

      Pages: 957-965

    • Peer Reviewed
  • [Journal Article] 線毛と嚢胞腎2011

    • Author(s)
      杉山紀之
    • Journal Title

      腎と透析 70(2)

      Pages: 237-242

  • [Journal Article] Abnormal Epithelial Cell Polarity and Ectopic Epidermal Growth Factor Receptor (EGFR) Expression Induced in Emx2 KO Embryonic Gonads.2010

    • Author(s)
      Kusaka M, Katoh-Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, Sugiyama N, Sugimoto Y, Okuno Y, Kodama R, Iizuka-Kogo A, Senda T, Sasaoka T, Kitamura K, Aizawa S, Morohashi KI.
    • Journal Title

      Endocrinology. 151(12)

      Pages: 5893-5904

    • Peer Reviewed
  • [Journal Article] ERK regulates renal cell proliferation and renal cyst expansion in inv mutant mice.2009

    • Author(s)
      Okumura Y, Sugiyama N, Tanimura S, Nishida M, Hamaoka K, Kohno M, Yokoyama T.
    • Journal Title

      Acta Histochem Cytochem. 42(2)

      Pages: 39-45

    • Peer Reviewed
  • [Journal Article] 嚢胞性腎疾患と繊毛2009

    • Author(s)
      横山尚彦、杉山紀之、芝大
    • Journal Title

      細胞工学 28(10)

      Pages: 1021-1026

  • [Presentation] Renal cystic diseases as a cilliopathy2011

    • Author(s)
      Yokoyama, T., Sugiyama, N., Shiba,D., Fukui, H., Nakata, K.
    • Organizer
      第116回解剖学会全国学術集会 抄録 The Journal of Physiological Sciences 61(suppl): s78(2011)
    • Place of Presentation
      横浜
    • Year and Date
      20110300
  • [Presentation] 嚢胞腎疾患と一次線毛2010

    • Author(s)
      杉山紀之
    • Organizer
      第13回埼玉若手腎臓病若手研究会 招待講演
    • Place of Presentation
      大宮 パレスホテル大宮
    • Year and Date
      2010-12-11
  • [Presentation] 繊毛と嚢胞腎2010

    • Author(s)
      杉山紀之
    • Organizer
      第32回腎臓セミナー 招待講演
    • Place of Presentation
      東京 海運ビル
    • Year and Date
      2010-08-28
  • [Presentation] Defective planar cell polarity/noncanonical Wnt signaling pathway and normal canonical Wnt/β-catenin signaling pathway in inv mice2010

    • Author(s)
      Sugiyama, N., Yokoyama, T.
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology "Cilia, Signaling and Human Disease"
    • Place of Presentation
      Portola Hotel & Spa, Monterey, California
    • Year and Date
      2010-02-23
  • [Presentation] 尿細管形態維持装置としての繊毛タンパクInvの機能2009

    • Author(s)
      横山尚彦、杉山紀之、芝大
    • Organizer
      第32回日本分子生物学会年会Workshop
    • Place of Presentation
      神奈川県・パシフィコ横浜
    • Year and Date
      2009-12-11
  • [Presentation] ERK Regulates Renal Cell Proliferation and Renal Cyst Expansion in inv Mutant Mice2009

    • Author(s)
      杉山紀之、奥村保子、横山尚彦
    • Organizer
      第50回日本組織細胞化学会
    • Place of Presentation
      滋賀・ピアザ淡海
    • Year and Date
      2009-09-26
  • [Presentation] invマウスの嚢胞腎におけるcanonical Wntシグナル経路の関与2009

    • Author(s)
      杉山紀之、横山尚彦
    • Organizer
      第52回日本腎臓学会
    • Place of Presentation
      神奈川県・パシフィコ横浜
    • Year and Date
      2009-06-04
  • [Remarks] ホームページ等

    • URL

      http://www.f.kpu-m.ac.jp/k/anat2/Projects/themal.html

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi