2010 Fiscal Year Final Research Report
Cytotoxic effect induced by phosphorylated alpha-synuclein and dopamine
| Project/Area Number |
21790830
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
SUGENO Naoto Tohoku University, 病院, 医員 (30509550)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 脳・神経 / タンパク質 |
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| Research Abstract |
Parkinson's disease is the second most common neurodegenerative disorder. Motor deficits which are result of nigral cell death are main feature of Parkinson's disease, but it is unclear the pathomechanisms of selective neuronal loss in substantia nigra. Previous studies revealed alpha-synuclein plays important role in molecular basis of Parkinson's disease. This study figure out that intracellular dopamine facilitates the toxicity of alpha-synuclein
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[Journal Article] Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease.2011
Author(s)
Baba T, Takeda A, Kikuchi A, Nishio Y, Hosokai Y, Hirayama K, Hasegawa T, Sugeno N, Suzuki K, Mori E, Takahashi S, Fukuda H, Itoyama Y.
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Journal Title
Mov Disord. 26巻
Pages: 621-628
Peer Reviewed
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[Journal Article] In vivo visualization of alpha-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl] -6-[2-(fluoro)ethoxy]benzoxazole positron emission tomography in multiple system atrophy.2010
Author(s)
Kikuchi A, Takeda A, Okamura N, Tashiro M, Hasegawa T, Furumoto S, Kobayashi M, Sugeno N, Baba T, Miki Y, Mori F, Wakabayashi K, Funaki Y, Iwata R, Takahashi S, Fukuda H, Arai H, Kudo Y, Yanai K, Itoyama Y.
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Journal Title
Brain. 133巻
Pages: 1772-1778
Peer Reviewed
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[Remarks] ホームページ等
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