2010 Fiscal Year Final Research Report
Searching for the immune target of acute inflammatory demyelinating polyneuropathy by using proteomic analysis.
| Project/Area Number |
21790833
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
SAWAI Setsu Chiba University, 大学院・医学研究院, 助教 (10400962)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 神経病態免疫学 / ギラン / バレー症候群 |
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| Research Abstract |
By using proteomic analysis, we searched for the immune target of Acute Inflammatory Demyelinating Polyneuropathy (AIDP). The target was considered to be the protein on the surface of the Schwann cell. We extract proteins from Schwannoma cell line, and we searched for the protein which reacted with the antibody (IgG) of the patients by 2 dimensional electrophoresis and western blotting. The proteins were identified with mass spectrometer. In the result, 3 proteins were thought to be the possible targets, and we found the autoantibodies against these proteins in the sera of the patients.
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[Journal Article] Altered axonal excitability properties in juvenile muscular atrophy of distal upper extremity (Hirayama disease).2011
Author(s)
Sawai S, Misawa S, Kanai K, Isose S, Shibuya K, Noto Y, Fujimaki Y, Sekiguchi Y, Nasu S, Nomura F, Kuwabara S.
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Journal Title
Clin Neurophysiol. 122(1)
Pages: 205-209
Peer Reviewed
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[Journal Article] Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis : Specificity, sensitivity, and a possible prognostic value.2011
Author(s)
Noto Y, Shibuya K, Sato Y, Kanai K, Misawa S, Sawai S, Mori M, Uchiyama T, Isose S, Nasu S, Sekiguchi Y, Fujimaki Y, Kasai T, Tokuda T, Nakagawa M, Kuwabara S.
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Journal Title
Amyotroph Lateral Scler. 12(2)
Pages: 140-143
Peer Reviewed
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[Journal Article] Multifocal conduction blocks in sarcoid peripheral neuropathy.2010
Author(s)
Sawai S, Misawa S, Kobayashi M, Kanai K, Isose S, Shibuya K, Sekiguchi Y, Nasu S, Noto Y, Fujimaki Y, Koga S, Ohtani R, Kuwabara S.
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Journal Title
Intern Med. 49(5)
Pages: 471-474
Peer Reviewed
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[Journal Article] Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group. Utility of the distal compound muscle action potential duration for diagnosis of demyelinating neuropathies.2009
Author(s)
Isose S, Kuwabara S, Kokubun N, Sato Y, Mori M, Shibuya K, Sekiguchi Y, Nasu S, Fujimaki Y, Noto Y, Sawai S, Kanai K, Hirata K, Misawa S
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Journal Title
J Peripher Nerv Syst. 14(3)
Pages: 151-158
Peer Reviewed
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[Journal Article] Physicochemical property changes of amino acid residues that accompany missense mutations in SCN1A affect epilepsy phenotype severity.2009
Author(s)
Kanai K, Yoshida S, Hirose S, Oguni H, Kuwabara S, Sawai S, Hiraga A, Fukuma G, Iwasa H, Kojima T, Kaneko S.
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Journal Title
J Med Genet. 46(10)
Pages: 671-679
Peer Reviewed
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